Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty

被引：37

作者：

Metallidis, S. ^{[1
]}

Topsis, D. ^{[2
]}

Nikolaidis, J. ^{[1
]}

Alexiadou, E. ^{[3
]}

Lazaraki, G. ^{[1
]}

Grovaris, L. ^{[2
]}

Theodoridou, A. ^{[1
]}

Nikolaidis, P. ^{[1
]}

机构：

[1] AHEPA Univ Hosp, Div Infect Dis, Dept Internal Med 1, Thessaloniki, Greece

[2] Hippokrateion Hosp, Dept Orthoped, Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki, Greece

来源：

JOURNAL OF CHEMOTHERAPY | 2007年 / 19卷 / 06期

关键词：

moxifloxacin; levofloxacin; osteomyelitis; HPLC; bone penetration;

D O I：

10.1179/joc.2007.19.6.682

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Penetration of levofloxacin and moxifloxacin into cancellous and cortical bone was studied using high-performance liquid chromatography (HPLC) in 16 patients who underwent routine total hip arthroplasty. Our results demonstrate a good degree of penetration into bone for both quinolones. The mean cancellous penetration was 53.86% for moxifloxacin and 54.13% for levofloxacin. The penetration into cortical bone was 41.59% and 34.26% respectively. The concentrations for both quinolones were above the minimum inhibitory concentration (MIC90s) for the most common pathogens, so they can be used for the treatment of osteomyelitis.

引用

页码：682 / 687

页数：6

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