Associations of acrylamide with non-alcoholic fatty liver disease in American adults: a nationwide cross-sectional study

被引:10
作者
Liu, Zhening [1 ,2 ]
Wang, Jinghua [1 ]
Chen, Shenghui [1 ]
Xu, Chengfu [1 ]
Zhang, Yu [2 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Fuli Inst Food Sci, Dept Food Sci & Nutr,Zhejiang Key Lab Agrofood Pr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
Fatty liver disease; Acrylamide; Association; Risk; INDEPENDENT RISK-FACTOR; HEMOGLOBIN ADDUCTS; UNITED-STATES; OBESITY; PREVALENCE; METABOLISM; HUMANS; CYP2E1; GLYCIDAMIDE; MECHANISMS;
D O I
10.1186/s12940-021-00783-2
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background Acrylamide (AA) is a toxicant to humans, but the association between AA exposure and the risk of non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, our objective is to examine the cross-sectional association between AA exposure and the risk of NAFLD in American adults. Methods A total of 3234 individuals who took part in the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2013-2016 were enrolled in the study. NAFLD was diagnosed by the U.S. Fatty Liver Index. Multivariable logistic regression models were applied to estimate the association between AA and NAFLD in the whole group and the non-smoking group. Results We discovered that in the whole group, serum hemoglobin adducts of AA (HbAA) were negatively associated with the prevalence of NAFLD after adjustment for various covariables (P for trend < 0.001). Compared with individuals in the lowest HbAA quartiles, the odds ratios (ORs) with 95% confidence intervals (CIs) in the highest HbAA quartiles were 0.61 (0.46-0.81) and 0.57 (0.36-0.88) in the whole group and the non-smoking group, respectively. In contrast, HbGA/HbAA showed a significantly positive correlation with the prevalence of NAFLD in both groups (P for trend < 0.001). In addition, HbGA was not significantly associated with NAFLD in the whole group or the non-smoking group. Conclusions HbAA is negatively associated with NAFLD whereas HbGA/HbAA is positively associated with NAFLD in adults in the U.S. Further studies are needed to clarify these relationships.
引用
收藏
页数:11
相关论文
共 65 条
  • [1] Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances
    Abdelmegeed, Mohamed A.
    Ha, Seung-Kwon
    Choi, Youngshim
    Akbar, Mohammed
    Song, Byoung-Joon
    [J]. CURRENT MOLECULAR PHARMACOLOGY, 2017, 10 (03) : 207 - 225
  • [2] Acrylamide levels and dietary exposure from foods in the United States, an update based on 2011-2015 data
    Abt, Eileen
    Robin, Lauren Posnick
    McGrath, Sara
    Srinivasan, Jannavi
    DiNovi, Michael
    Adachi, Yoko
    Chirtel, Stuart
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2019, 36 (10): : 1475 - 1490
  • [3] The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats
    Acaroz, Ulas
    Ince, Sinan
    Arslan-Acaroz, Damla
    Gurler, Zeki
    Kucukkurt, Ismail
    Demirel, Hasan Huseyin
    Arslan, Halil Ozancan
    Varol, Nuray
    Zhu, Kui
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2018, 118 : 745 - 752
  • [4] [Anonymous], 2020, LANCET GASTROENTEROL, V5, P419, DOI [10.1053/j.gastro.2019.11.312, 10.1016/S2468-1253(20)30091-1]
  • [5] Classification and Diagnosis of Diabetes
    不详
    [J]. DIABETES CARE, 2015, 38 : S8 - S16
  • [6] Induction of Vesicular Steatosis by Amiodarone and Tetracycline Is Associated with Up-regulation of Lipogenic Genes in HepaRG Cells
    Antherieu, Sebastien
    Rogue, Alexandra
    Fromenty, Bernard
    Guillouzo, Andre
    Robin, Marie-Anne
    [J]. HEPATOLOGY, 2011, 53 (06) : 1895 - 1905
  • [7] Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role
    Aubert, J.
    Begriche, K.
    Knockaert, L.
    Robin, M. A.
    Fromenty, B.
    [J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2011, 35 (10) : 630 - 637
  • [8] Definition of hyperuricemia and gouty conditions
    Bardin, Thomas
    Richette, Pascal
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2014, 26 (02) : 186 - 191
  • [9] Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver
    Begriche, Karima
    Massart, Julie
    Robin, Marie-Anne
    Borgne-Sanchez, Annie
    Fromenty, Bernard
    [J]. JOURNAL OF HEPATOLOGY, 2011, 54 (04) : 773 - 794
  • [10] Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers
    Bergmark, E
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (01) : 78 - 84