Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics

被引：13

作者：

Adriouach, Souad ^{[1
]}

Vorobiev, Vassily ^{[1
]}

Trefalt, Gregor ^{[2
]}

Allemann, Eric ^{[1
]}

Lange, Norbert ^{[1
]}

Babic, Andrej ^{[1
]}

机构：

[1] Univ Lausanne, Pharmaceut Technol, Sch Pharmaceut Sci, Univ Geneva, Geneva 4, Switzerland

[2] Univ Geneva, Lab Colloid & Surface Chem, Dept Chem, Geneva 4, Switzerland

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2019年 / 15卷 / 01期

关键词：

Nanoconstructs; Self-assembly; Pyropheophorbide-a; Photodynamic therapy; Fluorescence photodiagnosis; PHOTODYNAMIC THERAPY; IN-VITRO; DRUG-DELIVERY; CARBOXYMETHYL CHITOSAN; 5-AMINOLEVULINIC ACID; TARGETED DELIVERY; NANOPARTICLES; CANCER; SQUALENOYLATION; PHARMACOKINETICS;

D O I：

10.1016/j.nano.2018.09.013

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG: Ppa with an average size of 200 nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99.99% fluorescence self-quenching. The biocompatibility of the nanomaterial and cell phototoxicity under light irradiation were investigated on PC3 prostate tumor cells in vitro. SQ-PEG:Ppa showed excellent phototoxic effect at low light dose of 5.0 J/cm(2) as a consequence of efficient cell internalization of Ppa by the nanodelivery system. The diagnostic potential of SQ-PEG:Ppa nanoconstructs to deliver Ppa to tumors in vivo was demonstrated in chick embryo model implanted with U87MG glioblastoma micro tumors. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：243 / 251

页数：9

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