Heparin Resistance - Clinical Perspectives and Management Strategies

被引：123
作者：
Levy, Jerrold H. [1 ,2 ,3 ]
Connors, Jean M. [4 ,5 ]
机构：
[1] Duke Univ, Sch Med, Dept Anesthesiol, Durham, NC USA
[2] Duke Univ, Sch Med, Dept Crit Care, Durham, NC USA
[3] Duke Univ, Sch Med, Dept Surg, Durham, NC USA
[4] Brigham & Womens Hosp, Dept Med, Hematol Div, 75 Francis St, Boston, MA 02115 USA
[5] Harvard Med Sch, Boston, MA 02115 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 09期
关键词：
PARTIAL THROMBOPLASTIN TIME; VENOUS THROMBOEMBOLISM; ANTITHROMBIN-III; RANDOMIZED-TRIAL; XA; COAGULATION; ASSAY; ANTICOAGULATION; INHIBITOR;
D O I：
10.1056/NEJMra2104091
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heparin Resistance Heparin resistance is suspected when more heparin than usual is needed to achieve a therapeutic range of activated partial-thromboplastin time. Management may include increasing the heparin dose, supplementing antithrombin III levels, and using direct thrombin inhibitors.
引用
收藏
页码：826 / 832
页数：7
相关论文
共 40 条
[1]   Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass [J].
Avidan, MS ;
Levy, JH ;
van Aken, H ;
Feneck, RO ;
Latimer, RD ;
Ott, E ;
Martin, E ;
Birnbaum, DE ;
Bonfiglio, LJ ;
Kajdasz, DK ;
Despotis, GJ .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 130 (01) :107-113
[2]   THROMBOCYTOPENIA OCCURRING DURING ADMINISTRATION OF HEPARIN - PROSPECTIVE-STUDY IN 52 PATIENTS [J].
BELL, WR ;
TOMASULO, PA ;
ALVING, BM ;
DUFFY, TP .
ANNALS OF INTERNAL MEDICINE, 1976, 85 (02) :155-160
[3]   Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2 [J].
Beun, Robert ;
Kusadasi, Nuray ;
Sikma, Maaike ;
Westerink, Jan ;
Huisman, Albert .
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2020, 42 :19-20
[4]   COVID-19 and its implications for thrombosis and anticoagulation [J].
Connors, Jean M. ;
Levy, Jerrold H. .
BLOOD, 2020, 135 (23) :2033-2040
[5]   COMPARISON OF ACTIVATED COAGULATION LIME AND WHOLE-BLOOD HEPARIN MEASUREMENTS WITH LABORATORY PLASMA ANTI-XA HEPARIN CONCENTRATION IN PATIENTS HAVING CARDIAC OPERATIONS [J].
DESPOTIS, GJ ;
SUMMERFIELD, AL ;
JOIST, JH ;
GOODNOUGH, LT ;
SANTORO, SA ;
SPITZNAGEL, E ;
COX, JL ;
LAPPAS, DG .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1994, 108 (06) :1076-1082
[6]   Response of kaolin ACT to heparin: Evaluation with an automated assay and higher heparin doses [J].
Despotis, GJ ;
Alsoufiev, AL ;
Spitznagel, E ;
Goodnough, LT ;
Lappas, DG .
ANNALS OF THORACIC SURGERY, 1996, 61 (03) :795-799
[7]   THE IMPACT OF HEPARIN CONCENTRATION AND ACTIVATED CLOTTING TIME MONITORING ON BLOOD CONSERVATION - A PROSPECTIVE, RANDOMIZED EVALUATION IN PATIENTS UNDERGOING CARDIAC OPERATION [J].
DESPOTIS, GJ ;
JOIST, JH ;
HOGUE, CW ;
ALSOUFIEV, A ;
KATER, K ;
GOODNOUGH, LT ;
SANTORO, SA ;
SPITZNAGEL, E ;
ROSENBLUM, M ;
LAPPAS, DG .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1995, 110 (01) :46-54
[8]   Intraoperative Unfractionated Heparin Unresponsiveness during Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm following Administration of Andexanet Alfa for the Reversal of Rivaroxaban [J].
Eche, Ifeoma Mary ;
Elsamadisi, Pansy ;
Wex, Nicole ;
Wyers, Mark C. ;
Brat, Gabriel A. ;
Cunningham, Katherine ;
Bauer, Kenneth A. .
PHARMACOTHERAPY, 2019, 39 (08) :861-865
[9]   Diagnosis and Management of the Antiphospholipid Syndrome [J].
Garcia, David ;
Erkan, Doruk .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (21) :2010-2021
[10]   Parenteral Anticoagulants Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].
Garcia, David A. ;
Baglin, Trevor P. ;
Weitz, Jeffrey I. ;
Samama, Meyer Michel .
CHEST, 2012, 141 (02) :E24S-E43S
1234