A quaternary ammonium modified coumarin derivative for antimicrobial photodynamic therapy

被引:0
作者
Sun, Zhiyuan [1 ,3 ]
Zhou, Shaona [2 ]
Gu, Ying [2 ]
Zhao, Yuxia [1 ]
机构
[1] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100049, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源
LIGHT-BASED DIAGNOSIS AND TREATMENT OF INFECTIOUS DISEASES | 2018年 / 10479卷
基金
中国国家自然科学基金;
关键词
photodynamic therapy; antibacterial; antifungal; coumarin derivative; quaternary ammonium; PHOTOSENSITIZERS; SERIES; OXYGEN;
D O I
10.1117/12.2287086
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A new cationic modified coumarin derivative, 7-diethylamino-3-(3-(4-(trimethylbenzenaminium iodide) phenyl) acryloyl)-2H-chromen-2-one (1), was synthesized and characterized by H-1 NMR and mass spectra. It had a strong intramolecular charge transfer absorption band around 460 nm with large molar extinction coefficients of 3.94 x 10(4) M-1 cm(-1) in DMF and 3.86 x 10(4) M-1 cm(-1) in PBS, respectively. Moreover, a moderate singlet oxygen quantum yield of 0.16 was obtained for 1 in DMF. Using methylene blue (MB) under a 630 nm laser as reference, the in vitro antimicrobial photodynamic therapy (aPDT) activity of 1 against three strains, gram positive bacteria methicillin-resistant staphylococcus aureus (MRSA), negative bacteria acinetobacter baumannii (A. baumannii) and fungus Candida albicans (C. albicans), was carried out by irradiation with a 457 nm laser. It was shown that 1 had no dark toxicity to these bacteria when its concentration was up to 100 mu M, while under the 457 nm laser it could kill them effectively with an over 3 log CFU/ml decrease of the bacterial viability with its concentration up to 5 mu M. The aPDT capability of 1 against MRSA and A. baumannii was equivalent to that of MB. For C. albicans, 1 exhibited much better aPDT effect than MB.
引用
收藏
页数:8
相关论文
共 50 条
  • [41] Antimicrobial photodynamic therapy of Lactobacillus acidophilus by indocyanine green and 810-nm diode laser
    Ahrari, Farzaneh
    Shahabi, Mostafa
    Fekrazad, Reza
    Eslami, Neda
    Mazhari, Fatemeh
    Ghazvini, Kiarash
    Emrani, Niloofar
    [J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 24 : 145 - 149
  • [42] Cholesteryl Succinate-Modified Antimicrobial Peptides for Selective Sterilization of Staphylococcus aureus in Photodynamic Therapy
    Niu, Yuying
    Yan, Zihui
    Yang, Siqi
    Wang, Yuhui
    Wang, Xin
    Li, Chaoqing
    Bai, Yang
    Wang, Jianhao
    Shi, Honglei
    Zhao, Donghui
    [J]. ACS APPLIED NANO MATERIALS, 2025, 8 (05) : 2421 - 2431
  • [43] Photodynamic therapy: A special emphasis on nanocarrier-mediated delivery of photosensitizers in antimicrobial therapy
    Garapati, Chandrasekhar
    Boddu, Sai HS.
    Jacob, Shery
    Ranch, Ketan M.
    Patel, Chirag
    Babu, R. Jayachandra
    Tiwari, Amit K.
    Yasin, Haya
    [J]. ARABIAN JOURNAL OF CHEMISTRY, 2023, 16 (04)
  • [44] Photodynamic Antimicrobial Therapy Based on Conjugated Polymers
    Yuan, Huanxiang
    Li, Zelin
    Wang, Xiaoyu
    Qi, Ruilian
    [J]. POLYMERS, 2022, 14 (17)
  • [45] Clinical applications of antimicrobial photodynamic therapy in dentistry
    Gholami, Leila
    Shahabi, Shiva
    Jazaeri, Marzieh
    Hadilou, Mahdi
    Fekrazad, Reza
    [J]. FRONTIERS IN MICROBIOLOGY, 2023, 13
  • [46] Important cellular targets for antimicrobial photodynamic therapy
    Awad, Mariam M.
    Tovmasyan, Artak
    Craik, James D.
    Batinic-Haberle, Ines
    Benov, Ludmil T.
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 100 (17) : 7679 - 7688
  • [47] Synergistic antimicrobial effect of photodynamic therapy and ciprofloxacin
    Ronqui, Maria Rita
    Fogaca de Aguiar Coletti, Tatiana Maria Starck
    de Freitas, Laura Marise
    Miranda, Elaine Toscano
    Fontana, Carla Raquel
    [J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2016, 158 : 122 - 129
  • [48] Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects
    Mayr, Judith
    Bachl, Juergen
    Schlossmann, Jens
    Diaz Diaz, David
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (02)
  • [49] Physical and mathematical modeling of antimicrobial photodynamic therapy
    Buergermeister, Lisa
    Lopez, Fernando Romero
    Schulz, Wolfgang
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2014, 19 (07)
  • [50] Carbon Nanodots in Photodynamic Antimicrobial Therapy: A Review
    Knoblauch, Rachael
    Geddes, Chris D.
    [J]. MATERIALS, 2020, 13 (18)