Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

被引：29

作者：

Moreira, Andre F. ^{[1
]}

Rodrigues, Carolina F. ^{[1
]}

Reis, Catarina A. ^{[1
,2
]}

Costa, Elisabete C. ^{[1
]}

Ferreira, Paula ^{[3
]}

Correia, Ilidio J. ^{[1
,3
]}

机构：

[1] UBI, CICS, P-6200506 Covilha, Portugal

[2] Univ Nova Lisboa, Fac Ciencias & Tecnol, REQUIMTE Dept Quim, UCIBIO, P-2829516 Caparica, Portugal

[3] Univ Coimbra, CIEPQF Dept Engn Quim, Rua 13 Silvio Lima, P-3030790 Coimbra, Portugal

来源：

NANOMEDICINE | 2018年 / 13卷 / 20期

关键词：

cancer; combinatorial therapy; drug-delivery; gold-core silica shell nanorods; photothermal therapy; NEAR-INFRARED LIGHT; MESOPOROUS SILICA; NANOPARTICLES SYNTHESIS; OPTICAL-PROPERTIES; CELLULAR UPTAKE; DRUG-DELIVERY; SURFACE; ABLATION; HYPERTHERMIA; CYTOTOXICITY;

D O I：

10.2217/nnm-2018-0179

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer. [GRAPHICS]

引用

页码：2611 / 2628

页数：18

共 71 条

[71] pH-Sensitive Gold Nanorods with a Mesoporous Silica Shell for Drug Release and Photothermal Therapy [J].