Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

被引：29
作者：
Moreira, Andre F. [1 ]
Rodrigues, Carolina F. [1 ]
Reis, Catarina A. [1 ,2 ]
Costa, Elisabete C. [1 ]
Ferreira, Paula [3 ]
Correia, Ilidio J. [1 ,3 ]
机构：
[1] UBI, CICS, P-6200506 Covilha, Portugal
[2] Univ Nova Lisboa, Fac Ciencias & Tecnol, REQUIMTE Dept Quim, UCIBIO, P-2829516 Caparica, Portugal
[3] Univ Coimbra, CIEPQF Dept Engn Quim, Rua 13 Silvio Lima, P-3030790 Coimbra, Portugal
来源：
NANOMEDICINE | 2018年 / 13卷 / 20期
关键词：
cancer; combinatorial therapy; drug-delivery; gold-core silica shell nanorods; photothermal therapy; NEAR-INFRARED LIGHT; MESOPOROUS SILICA; NANOPARTICLES SYNTHESIS; OPTICAL-PROPERTIES; CELLULAR UPTAKE; DRUG-DELIVERY; SURFACE; ABLATION; HYPERTHERMIA; CYTOTOXICITY;
D O I：
10.2217/nnm-2018-0179
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer. [GRAPHICS]
引用
收藏
页码：2611 / 2628
页数：18
相关论文
共 71 条
[1]   Distance and Plasmon Wavelength Dependent Fluorescence of Molecules Bound to Silica-Coated Gold Nanorods [J].
Abadeer, Nardine S. ;
Brennan, Marshall R. ;
Wilson, William L. ;
Murphy, Catherine J. .
ACS NANO, 2014, 8 (08) :8392-8406
[2]   Combinatorial drug therapy for cancer in the post-genomic era [J].
Al-Lazikani, Bissan ;
Banerji, Udai ;
Workman, Paul .
NATURE BIOTECHNOLOGY, 2012, 30 (07) :679-691
[3]   Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity and Surface Effects [J].
Alkilany, Alaaldin M. ;
Nagaria, Pratik K. ;
Hexel, Cole R. ;
Shaw, Timothy J. ;
Murphy, Catherine J. ;
Wyatt, Michael D. .
SMALL, 2009, 5 (06) :701-708
[4]   Effect of Tumor Microenvironment on Selective Uptake of Boric Acid in HepG2 Human Hepatoma Cells [J].
Bai, Yu-Chi ;
Hsia, Yu-Chun ;
Lin, Yu-Ting ;
Chen, Kuan-Hao ;
Chou, Fong-In ;
Yang, Chia-Min ;
Chuang, Yung-Jen .
ANTICANCER RESEARCH, 2017, 37 (11) :6347-6353
[5]   Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier [J].
Bernd, Alexandra ;
Ott, Melanie ;
Ishikawa, Hiroshi ;
Schroten, Horst ;
Schwerk, Christian ;
Fricker, Gert .
PHARMACEUTICAL RESEARCH, 2015, 32 (09) :2973-2982
[6]   Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules [J].
Boissenot, Tanguy ;
Bordat, Alexandre ;
Larrat, Benoit ;
Varna, Mariana ;
Chacun, Helene ;
Paci, Angelo ;
Poinsignon, Vianney ;
Fattal, Elias ;
Tsapis, Nicolas .
JOURNAL OF CONTROLLED RELEASE, 2017, 264 :219-227
[7]   Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy [J].
Chen, Yun-Sheng ;
Frey, Wolfgang ;
Kim, Seungsoo ;
Homan, Kimberly ;
Kruizinga, Pieter ;
Sokolov, Konstantin ;
Emelianov, Stanislav .
OPTICS EXPRESS, 2010, 18 (09) :8867-8877
[8]   Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo [J].
Cheng, Xiaju ;
Sun, Rui ;
Yin, Ling ;
Chai, Zhifang ;
Shi, Haibin ;
Gao, Mingyuan .
ADVANCED MATERIALS, 2017, 29 (06)
[9]   Thermal ablation of tumours: biological mechanisms and advances in therapy [J].
Chu, Katrina F. ;
Dupuy, Damian E. .
NATURE REVIEWS CANCER, 2014, 14 (03) :199-208
[10]  
Colilla M., 2015, The Sol-Gel Handbook-Synthesis, Characterization, and Applications: Synthesis, Characterization and Applications, 3-Volume Set, V3, P1309
12345678