Effect of relevant factors on radiation-induced nasopharyngeal ulcer in patients with primary nasopharyngeal carcinoma treated with intensity-modulated radiation therapy

被引：3
作者：
Fei, Zhaodong [1 ]
Chen, Taojun [1 ]
Qiu, Xiufang [1 ]
Chen, Chuanben [1 ]
机构：
[1] Fujian Med Univ, Dept Radiotherapy, Fujian Canc Hosp, Canc Hosp, Fuma Rd, Fuzhou 350014, Fujian, Peoples R China
来源：
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | 2020年 / 5卷 / 02期
关键词：
dose-volume; intensity-modulated radiation therapy; nasopharyngeal carcinoma; nutrition-related parameters; radiation-induced nasopharyngeal ulcer; LATE TOXICITIES; TUMOR VOLUME; RADIOTHERAPY; CANCER; HEAD; STAGE; RISK;
D O I：
10.1002/lio2.365
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective To analyze the correlation between relevant factors and radiation-induced nasopharyngeal ulcer (RINU) in primary nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT). Methods Clinical data were collected for 599 patients with newly diagnosed NPC who had completed IMRT. The entire cohort was randomly divided into two subgroups. The relationship between RINU and IMRT dose-volume were statistically analyzed with ROC curves and the Chi-square test. Nutritional status during and after treatment was compared between patients with vs without RINU. Results The results obtained showed that dose-volume had no effect on the incidence of RINU (P > .05). Nutrition-related parameters differed significantly between patients with vs without RINU (P < .05). Conclusion The results obtained show that the incidence of RINU is not related to IMRT dose-volume in the treatment of primary NPC. The incidence of RINU was found to be related to nutritional status during and after radiation therapy. Level of Evidence 2a
引用
收藏
页码：228 / 234
页数：7
相关论文
共 26 条
[1]  
Auyeung KM, 2003, AM J NEURORADIOL, V24, P1449
[2]   Estimation of cancer burden in Guangdong Province, China in 2009 [J].
Cao, Su-Mei ;
Xu, Yan-Jun ;
Lin, Guo-Zhen ;
Huang, Qi-Hong ;
Wei, Kuang-Rong ;
Xie, Shang-Hang ;
Liu, Qing .
CHINESE JOURNAL OF CANCER, 2015, 34 :1-8
[3]   Significance of Primary Tumor Volume and T-stage on Prognosis in Nasopharyngeal Carcinoma Treated with Intensity-modulated Radiation Therapy [J].
Chen, Chuanben ;
Fei, Zhaodong ;
Pan, Jianji ;
Bai, Penggang ;
Chen, Lisha .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 41 (04) :537-542
[4]   Effectiveness and Toxicities of Intensity-Modulated Radiotherapy for Patients with Locally Recurrent Nasopharyngeal Carcinoma [J].
Chen, Hai-yan ;
Ma, Xiu-mei ;
Ye, Ming ;
Hou, Yan-li ;
Xie, Hua-Ying ;
Bai, Yong-rui .
PLOS ONE, 2013, 8 (09)
[5]   Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis [J].
Chen, Ming-Yuan ;
Mai, Hai-Qiang ;
Sun, Rui ;
Guo, Xiang ;
Zhao, Chong ;
Hong, Ming-Huang ;
Hua, Yi-Jun .
CHINESE JOURNAL OF CANCER, 2013, 32 (10) :533-538
[6]   Nasopharyngeal carcinoma [J].
Chua, Melvin L. K. ;
Wee, Joseph T. S. ;
Hui, Edwin P. ;
Chan, Anthony T. C. .
LANCET, 2016, 387 (10022) :1012-1024
[7]   Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies [J].
Elting, Linda S. ;
Cooksley, Catherine D. ;
Chambers, Mark S. ;
Garden, Adam S. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 68 (04) :1110-1120
[8]   Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests [J].
Greiner, M ;
Pfeiffer, D ;
Smith, RD .
PREVENTIVE VETERINARY MEDICINE, 2000, 45 (1-2) :23-41
[9]   Hypoxia imaging with [F-18] FMISO-PET in head and neck cancer: Potential for guiding intensity modulated radiation therapy in overcoming hypoxia-induced treatment resistance [J].
Hendrickson, Kristi ;
Phillips, Mark ;
Smith, Wade ;
Peterson, Lanell ;
Krohn, Kenneth ;
Rajendran, Joseph .
RADIOTHERAPY AND ONCOLOGY, 2011, 101 (03) :369-375
[10]   Long-term late toxicities and quality of life for survivors of nasopharyngeal carcinoma treated with intensity-modulated radiotherapy versus non-intensity-modulated radiotherapy [J].
Huang, Tai-Lin ;
Chien, Chih-Yen ;
Tsai, Wen-Ling ;
Liao, Kuan-Cho ;
Chou, Shang-Yu ;
Lin, Hsin-Ching ;
Luo, Sheng Dean ;
Lee, Tsair-Fwu ;
Lee, Chien-Hung ;
Fang, Fu-Min .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 :E1026-E1032
123