Altered topological organization of brain structural network in Chinese children with developmental dyslexia

被引:23
|
作者
Liu, Kai [1 ,2 ,3 ,4 ]
Shi, Lin [5 ,6 ]
Chen, Feiyan [7 ]
Waye, Mary M. Y. [8 ]
Lim, Cadmon K. P. [9 ]
Cheng, Pui-wan [10 ]
Luk, Sarah S. H. [10 ]
Mok, Vincent C. T. [5 ,6 ]
Chu, Winnie C. W. [1 ,2 ]
Wang, Defeng [1 ,2 ,3 ,4 ,11 ]
机构
[1] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Res Ctr Med Image Comp, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Shun Hing Inst Adv Engn, Shatin, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[6] Chinese Univ Hong Kong, Chow Yuk Ho Technol Ctr Innovat Med, Shatin, Hong Kong, Peoples R China
[7] Zhejiang Univ, Dept Phys, Biox Lab, Hangzhou 310003, Zhejiang, Peoples R China
[8] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
[9] Chinese Univ Hong Kong, Dept Med & Therapeut, Div Endocrinol & Diabet, Shatin, Hong Kong, Peoples R China
[10] Chinese Univ Hong Kong, Dept Educ Psychol, Shatin, Hong Kong, Peoples R China
[11] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Developmental dyslexia; Magnetic resonance imaging; Brain volume; Topological analysis; Structural network; CORTICAL THICKNESS; CORTEX; ADULTS; MRI; CONNECTIVITY;
D O I
10.1016/j.neulet.2015.01.037
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Increasing evidence indicates that developmental dyslexia (DD) is a "disconnection syndrome", and new probes of connectome were applied to investigate the "disconnection" in DD. However, there is a lack of brain connectome studies of Chinese dyslexics, who may have a different neural impairment pattern due to the logographic nature of Chinese. The aim of this study was to investigate the topological organization characteristics of the DD brain using a structural network based analysis on the volumetric covariance, which is a method with the advantage of reflecting brain developmental changes. Twenty-five children diagnosed with DD and twenty-five typically developing controls were included. The structural networks based on the pair-wise correlation of gray matter volume from 90 brain regions were constructed for the two groups and compared. Compared to controls, the structural network of dyslexic children exhibited significantly increased local efficiency combined with a tendency of decreased global efficiency and prolonged characteristic path length, thus reflecting a more locally specialized topological organization. Two brain areas showed significantly altered local regional network properties: the left precentral gyrus with increased b(i), and the right Heschl's gyrus with decreased b(i) and k(i). Moreover, a series of hub regions (especially the right fronto-temporal regions) identified in the network of typically developing children were not presented in the brain of DD. To our knowledge, this is the first whole-brain structural network study on Chinese dyslexics. This study provides evidence of brain topological organization changes in Chinese children with DD, and thus may help shed light on its neurobiological basis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:169 / 175
页数:7
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