Alendronate sodium-polymeric nanoparticles display low toxicity in gastric mucosal of rats and Ofcol II cells

被引：4

作者：

Iles, Bruno ^{[1
]}

Noleto, Isabela Ribeiro de Sa Guimaraes ^{[1
,2
]}

Dourado, Flaviane Franca ^{[2
]}

Ribeiro, Fabio de Oliveira Silva ^{[2
]}

Araujo, Alyne Rodrigues de ^{[2
]}

Oliveira, Taiane Maria de ^{[2
]}

Souza, Jessica Maria Teles ^{[3
]}

Barros, Ayslan Batista ^{[3
]}

Sousa, Gabrielle Costa ^{[1
,2
]}

de Jesus Oliveira, Antonia Carla ^{[4
]}

Veras, Mariana de Oliveira Viana ^{[5
]}

Leitao, Renata Ferreira de Carvalho ^{[5
]}

Leite, Jose Roberto de Souza de Almeida ^{[6
]}

Silva, Durcilene Alves da ^{[2
]}

Medeiros, Jand Venes Rolim ^{[1
,2
]}

Martins, Conceicao da Silva ^{[5
]}

机构：

[1] Fed Univ Parnaiba Delta, Lab Inflammat & Gastrointestinal Disorders Lafid, Av Sao Sebastiao 2819, BR-64202020 Parnaiba, Brazil

[2] Fed Univ Parnaiba Delta, Biotechnol & Biodivers Res Ctr Biotec, Av Sao Sebastiao 2819, BR-64202020 Parnaiba, Brazil

[3] Fed Univ Parnaiba Delta, Parnaiba Delta Cell Culture Lab LCC Delta, Av Sao Sebastiao 2819, YR-64202020 Parnaiba, Brazil

[4] Univ Fed Pernambuco, Qual Control Ctr Med & Correlates NCQMC, Dept Pharmaceut Sci, Av Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil

[5] Univ Fed Ceara, Nucleus Studies Microscopy & Image Proc NEMPI, Rua Alexandre Barauna 994, BR-60430160 Fortaleza, Brazil

[6] Univ Brasilia, Ctr Res Appl Morphol & Immunol Nupmia, Campus Darcy Ribeiro Asa Norte Brasilia DF, BR-70910900 Brasilia, Brazil

来源：

NANOIMPACT | 2021年 / 24卷

关键词：

Polymeric nanoparticle; Alendronate; Cashew gum; Red Angico gum; Gastric lesion; NITROGEN-CONTAINING BISPHOSPHONATE; LOADED PLGA NANOPARTICLES; CASHEW GUM; IN-VITRO; PARTICLE-SIZE; ANACARDIUM-OCCIDENTALE; INCLUSION COMPLEXES; SUSTAINED-RELEASE; DELIVERY-SYSTEMS; DRUG;

D O I：

10.1016/j.impact.2021.100355

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The use of bisphosphonates constitutes the gold-standard therapy for the control and treatment of bone diseases. However, its long-term use may lead to gastric problems, which limits the treatment. Thus, this study aimed to formulate a nanostructured system with biodegradable polymers for the controlled release of alendronate sodium. The nanoparticles were characterized, and its gastric toxicity was investigated in rats. The synthesis process proved to be effective for encapsulating alendronate sodium, exhibiting nanoparticles with an average size of 51.02 nm and 98.5% of alendronate sodium incorporation. The release tests demonstrated a controlled release of the drug in 420 min, while the morphological analyzes showed spherical shapes and no apparent roughness. The biological tests demonstrated that the alendronate sodium nanoformulation reversed the gastric lesions, maintaining the normal levels of malondialdehyde and myeloperoxidase. Also, the encapsulated alendronate sodium showed no toxicity in murine osteoblastic cells, even at high concentrations.

引用

页数：12

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