Glioblastoma in natalizumab-treated multiple sclerosis patients

被引：9

作者：

Morales, Fabian Sierra ^{[1
,2
,3
]}

Wright, Robert B. ^{[2
]}

Novo, Jorge E. ^{[4
]}

Arvanitis, Leonidas D. ^{[4
]}

Stefoski, Dusan ^{[2
,3
]}

Koralnik, Igor J. ^{[1
,2
]}

机构：

[1] Rush Univ, Med Ctr, Sect Neuroinfect Dis, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Multiple Sclerosis Ctr, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2017年 / 4卷 / 07期

基金：

美国国家卫生研究院;

关键词：

NERVOUS-SYSTEM LYMPHOMA; LONG-TERM SAFETY; MELANOMA; RISK;

D O I：

10.1002/acn3.428

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present two natalizumab-treated multiple sclerosis patients who developed glioblastoma multiforme (GBM) with variable outcomes. One patient had an isocitrate dehydrogenase (IDH)-wildtype GBM with aggressive behavior, who declined treatment and died 13 weeks after symptoms onset. The other patient underwent resection of an IDH-mutant secondary GBM that arose from a previously diagnosed grade II astrocytoma. He is still alive 5 years after the diagnosis of GBM. JC virus was not detected in either case. Whether natalizumab played a role in the development of GBM in those patients deserves further investigation.

引用

页码：512 / 516

页数：5

共 23 条

[1] Melanoma in multiple sclerosis treated with natalizumab: causal association or coincidence? [J].

Bergamaschi, Roberto ;

Montomoli, Cristina .

MULTIPLE SCLEROSIS, 2009, 15 (12) :1532-1533

[2] β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma [J].

Carbonell, W. Shawn ;

Delay, Michael ;

Jahangiri, Arman ;

Park, Catherine C. ;

Aghi, Manish K. .

CANCER RESEARCH, 2013, 73 (10) :3145-3154

[3] Multiple sclerosis [J].

Compston, Alastair ;

Coles, Alasdair .

LANCET, 2008, 372 (9648) :1502-1517

[4] Immune Response in Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Intranodal Autologous Tumor Lysate-dendritic Cell Vaccination After Radiation Chemotherapy [J].

Fadul, Camilo E. ;

Fisher, Jan L. ;

Hampton, Thomas H. ;

Lallana, Enrico C. ;

Li, Zhongze ;

Gui, Jiang ;

Szczepiorkowski, Zbigniew M. ;

Tosteson, Tor D. ;

Rhodes, C. Harker ;

Wishart, Heather A. ;

Lewis, Lionel D. ;

Ernstoff, Marc S. .

JOURNAL OF IMMUNOTHERAPY, 2011, 34 (04) :382-389

[5] Subsequent brain tumors in patients with autoimmune disease [J].

Hemminki, Kari ;

Liu, Xiangdong ;

Forsti, Asta ;

Ji, Jianguang ;

Sundquist, Jan ;

Sundquist, Kristina .

NEURO-ONCOLOGY, 2013, 15 (09) :1142-1150

[6] CANCER RISK AMONG PATIENTS WITH MULTIPLE SCLEROSIS AND THEIR PARENTS [J].

Hofer, Silvia ;

Linnebank, Michael ;

Weller, Michael .

NEUROLOGY, 2010, 74 (07) :614-615

[7] Genetic characterization of gliomas arising in patients with multiple sclerosis [J].

Khalil, Adam ;

Serracino, Hilary ;

Damek, Denise M. ;

Ney, Douglas ;

Lillehei, Kevin O. ;

Kleinschmidt-DeMasters, B. K. .

JOURNAL OF NEURO-ONCOLOGY, 2012, 109 (02) :261-272

[8] The prognostic relevance of molecular alterations in glioblastomas for patients age < 50 years [J].

Korshunov, A ;

Sycheva, R ;

Golanov, A .

CANCER, 2005, 104 (04) :825-832

[9] Association of melanoma and natalizumab therapy in the Italian MS population: a second case report [J].

Laroni, A. ;

Bedognetti, M. ;

Uccelli, A. ;

Capello, E. ;

Mancardi, G. L. .

NEUROLOGICAL SCIENCES, 2011, 32 (01) :181-182

[10] Non-Hodgkin Lymphoma of the Stomach in a Patient Treated with Natalizumab [J].

Law, Jennie Y. ;

Kim, Dong W. ;

Sturgis, Ariel ;

Naina, Harris V. .

CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2015, 9 :61-63

← 1 2 3 →