Subacute Cutaneous Lupus Erythematosus Exacerbated or Induced by Chemotherapy

被引：0
|
作者：
Funke, Alisa A. [1 ]
Kulp-Shorten, Carol L. [1 ]
Callen, Jeffrey P. [1 ]
机构：
[1] Univ Louisville, Sch Med, Dept Med, Div Dermatol, Louisville, KY 40292 USA
来源：
ARCHIVES OF DERMATOLOGY | 2010年 / 146卷 / 10期
关键词：
CAPECITABINE; SUBSET;
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Subacute cutaneous lupus erythematosus (SCLE), characterized by nonscarring, photodistributed, annular or papulosquamous plaques, is occasionally induced by medication. It has been strongly associated with antihypertensive medications and terbinafine hydrochloride. Observation: We describe 3 women with breast cancer who developed SCLE-like eruptions after being administered doxorubicin hydrochloride and cyclophosphamide. Biopsy specimens of all 3 patients demonstrated an interface dermatitis. Treatment consisted of topical and/or systemic corticosteroids, photoprotection, and switching the chemotherapeutic regimens. Conclusions: Based on clinicopathologic correlation and timing of chemotherapy exposure, the patients were believed to have drug-induced SCLE. Although cutaneous eruption, pruritus, and photosensitivity are known adverse effects of doxorubicin, to our knowledge there has been only 1 previously reported case of doxorubicin-induced SCLE.
引用
收藏
页码：1113 / 1116
页数：4
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