The Antibiotic Development Pipeline for Multidrug-Resistant Gram-Negative Bacilli: Current and Future Landscapes

被引:14
|
作者
Talbot, George H. [1 ]
机构
[1] Talbot Advisors LLC, Wayne, PA USA
来源
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2010年 / 31卷
关键词
DRUGS;
D O I
10.1086/655988
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Development of antibiotics to treat infections caused by multidrug-resistant gram-negative bacilli has lagged significantly behind development of antibiotics to treat infections with gram-positive pathogens. Although a few promising drugs have entered early clinical development, more must be done to preserve the utility of currently available antibiotics and to ensure a pipeline of efficacious, safe antibacterials.
引用
收藏
页码:S55 / S58
页数:4
相关论文
共 50 条
  • [41] THE EMERGENCE OF ANTIBIOTIC-RESISTANT GRAM-NEGATIVE BACILLI
    SANFORD, JP
    FAVOUR, CB
    MAO, FH
    JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1955, 45 (04): : 540 - 545
  • [42] Machine Learning and Multidrug-Resistant Gram-Negative Bacteria: An Interesting Combination for Current and Future Research
    Giacobbe, Daniele Roberto
    Mora, Sara
    Giacomini, Mauro
    Bassetti, Matteo
    ANTIBIOTICS-BASEL, 2020, 9 (02):
  • [43] Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic
    Mood, Elnaz Harifi
    Goltermann, Lise
    Brolin, Camilla
    Cavaco, Lina M.
    Nejad, Alireza Japoni
    Yavari, Niloofar
    Frederiksen, Nicki
    Franzyk, Henrik
    Nielsen, Peter E.
    ACS INFECTIOUS DISEASES, 2021, 7 (08): : 2152 - 2163
  • [44] Antibiotic adjuvants against multidrug-resistant Gram-negative bacteria: important component of future antimicrobial therapy
    Li, Wenwen
    Tao, Zhen
    Zhou, Motan
    Jiang, Huilin
    Wang, Liudi
    Ji, Bingjie
    Zhao, Yongshan
    MICROBIOLOGICAL RESEARCH, 2024, 287
  • [45] An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
    Alysha G. Elliott
    Johnny X. Huang
    Søren Neve
    Johannes Zuegg
    Ingrid A. Edwards
    Amy K. Cain
    Christine J. Boinett
    Lars Barquist
    Carina Vingsbo Lundberg
    Jason Steen
    Mark S. Butler
    Mehdi Mobli
    Kaela M. Porter
    Mark A. T. Blaskovich
    Sergio Lociuro
    Magnus Strandh
    Matthew A. Cooper
    Nature Communications, 11
  • [46] Antibiotic synergy testing for multidrug-resistant Gram-negative pathogens in a Greek ICU
    E Douka
    E Perivoliot
    E Kraniotaki
    M Nepka
    C Routsi
    K Fountoulis
    A Skoutelis
    S Zakynthinos
    Critical Care, 19 (Suppl 1):
  • [47] An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
    Elliott, Alysha G.
    Huang, Johnny X.
    Neve, Soren
    Zuegg, Johannes
    Edwards, Ingrid A.
    Cain, Amy K.
    Boinett, Christine J.
    Barquist, Lars
    Lundberg, Carina Vingsbo
    Steen, Jason
    Butler, Mark S.
    Mobli, Mehdi
    Porter, Kaela M.
    Blaskovich, Mark A. T.
    Lociuro, Sergio
    Strandh, Magnus
    Cooper, Matthew A.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [48] Multidrug-resistant bacteria: overcoming antibiotic permeability barriers of Gram-negative bacteria
    Savage, PB
    ANNALS OF MEDICINE, 2001, 33 (03) : 167 - 171
  • [49] Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli
    George G. Zhanel
    Alyssa R. Golden
    Sheryl Zelenitsky
    Karyn Wiebe
    Courtney K. Lawrence
    Heather J. Adam
    Temilolu Idowu
    Ronald Domalaon
    Frank Schweizer
    Michael A. Zhanel
    Philippe R. S. Lagacé-Wiens
    Andrew J. Walkty
    Ayman Noreddin
    Joseph P. Lynch III
    James A. Karlowsky
    Drugs, 2019, 79 : 271 - 289
  • [50] Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli
    Zhanel, George G.
    Golden, Alyssa R.
    Zelenitsky, Sheryl
    Wiebe, Karyn
    Lawrence, Courtney K.
    Adam, Heather J.
    Idowu, Temilolu
    Domalaon, Ronald
    Schweizer, Frank
    Zhanel, Michael A.
    Lagace-Wiens, Philippe R. S.
    Walkty, Andrew J.
    Noreddin, Ayman
    Lynch, Joseph P., III
    Karlowsky, James A.
    DRUGS, 2019, 79 (03) : 271 - 289