Gold Nanoparticle-Based Biodetection for Chip-Based Portable Diagnosis Systems

被引：6

作者：

Li, Shifeng ^{[1
]}

Goluch, Edgar ^{[1
]}

Liu, Chang ^{[1
]}

Szegedi, Sandra ^{[1
]}

Shaikh, Kashan ^{[1
]}

Ahmed, Faysal ^{[1
]}

Hu, Alan ^{[1
]}

Zhao, Shenshen ^{[1
]}

机构：

[1] Northwestern Univ, Dept Mech Engn, MedX Lab, McCormick Sch Engn, Evanston, IL 60208 USA

来源：

JALA | 2010年 / 15卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

gold nanoparticles; lab-on-chip; biobarcode; DIP-PEN NANOLITHOGRAPHY; SILICONE ELASTOMER; DNA DETECTION; ARRAY; AMPLIFICATION; SENSITIVITY; PROBES; ASSAY; PCR;

D O I：

10.1016/j.jala.2009.11.001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We review the past development of highly sensitive and selective gold nanoparticle (AuNP)-based assays of protein and DNA biomarkers for chip-based detection systems. The microfluidic systems, various assays, and preliminary laboratory results are shown. AuNP-based biodetection assays provide low detection threshold, offering promises for multiplexed diagnostics of many forms of disease markers. (JALA 2010;15:107-13)

引用

页码：107 / 113

页数：7

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