Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms

被引：66

作者：

Atyeo, Caroline G. ^{[1
,2
]}

Shook, Lydia L. ^{[3
,4
]}

Brigida, Sara ^{[4
]}

De Guzman, Rose M. ^{[3
,4
]}

Demidkin, Stepan ^{[4
]}

Muir, Cordelia ^{[4
]}

Akinwunmi, Babatunde ^{[5
]}

Baez, Arantxa Medina ^{[4
]}

McSweeney, Erin ^{[1
]}

Burns, Madeleine ^{[4
]}

Nayak, Ruhi ^{[3
,6
,7
,8
]}

Kumar, Maya K. ^{[4
]}

Patel, Chinmay D. ^{[5
]}

Fialkowski, Allison ^{[5
]}

Cvrk, Dana ^{[4
,6
]}

Goldfarb, Ilona T. ^{[3
]}

Yonker, Lael M. ^{[3
]}

Fasano, Alessio ^{[6
,7
,8
]}

Balazs, Alejandro B. ^{[1
]}

Elovitz, Michal A. ^{[9
]}

Gray, Kathryn J. ^{[5
]}

Alter, Galit ^{[1
]}

Edlow, Andrea G. ^{[3
,4
]}

机构：

[1] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[2] Harvard Univ, Div Med Sci, PhD Program Virol, Boston, MA 02115 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Vincent Ctr Reprod Biol, Boston, MA 02114 USA

[5] Harvard Med Sch, Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA

[6] Massachusetts Gen Hosp, Mucosal Immunol & Biol Res Ctr, Boston, MA 02114 USA

[7] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA

[8] Harvard Med Sch, Boston, MA 02115 USA

[9] Univ Penn, Dept Obstet & Gynecol, Maternal & Child Hlth Res Program, Philadelphia, PA 19104 USA

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

PERTUSSIS TDAP IMMUNIZATION; A H1N1 VACCINE; PREGNANT-WOMEN; DIPHTHERIA; TETANUS; STATES; IMMUNOGENICITY; ASSOCIATION; PROTECTION; EXCLUSION;

D O I：

10.1038/s41467-022-31169-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pregnant individuals infected with SARS-CoV-2 are at high risk of morbidity and mortality, in addition to adverse pregnancy outcomes, yet little is known regarding trimester-specific immunity and maternal protection from COVID-19 vaccine platforms. Authors utilise a systems serology approach to characterise the material antibody response and the transplacental antibody transfer, dependent on vaccine platform and trimester of vaccination. The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of vaccination in pregnancy impact maternal and neonatal immunity. Here, we characterize the antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 vaccination in 158 pregnant individuals and evaluate transplacental antibody transfer by profiling maternal and umbilical cord blood in 175 maternal-neonatal dyads. These analyses reveal lower vaccine-induced functions and Fc receptor-binding after Ad26.COV2.S compared to mRNA vaccination and subtle advantages in titer and function with mRNA-1273 versus BN162b2. mRNA vaccines have higher titers and functions against SARS-CoV-2 variants of concern. First and third trimester vaccination results in enhanced maternal antibody-dependent NK-cell activation, cellular and neutrophil phagocytosis, and complement deposition relative to second trimester. Higher transplacental transfer ratios following first and second trimester vaccination may reflect placental compensation for waning maternal titers. These results provide novel insight into the impact of platform and trimester of vaccination on maternal humoral immune response and transplacental antibody transfer.

引用

页数：15

共 92 条

[1] The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - A prospective study [J].

Abu Raya, Bahaa ;

Srugo, Isaac ;

Kessel, Aharon ;

Peterman, Michael ;

Bader, David ;

Gonen, Ron ;

Bamberger, Ellen .

VACCINE, 2014, 32 (44) :5787-5793

[2] Maternal Immunological Adaptation During Normal Pregnancy [J].

Abu-Raya, Bahaa ;

Michalski, Christina ;

Sadarangani, Manish ;

Lavoie, Pascal M. .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[3] An immune clock of human pregnancy [J].

Aghaeepour, Nima ;

Ganio, Edward A. ;

Mcilwain, David ;

Tsai, Amy S. ;

Tingle, Martha ;

Van Gassen, Sofie ;

Gaudilliere, Dyani K. ;

Baca, Quentin ;

McNeil, Leslie ;

Okada, Robin ;

Ghaemi, Mohammad S. ;

Furman, David ;

Wong, Ronald J. ;

Winn, Virginia D. ;

Druzin, Maurice L. ;

El-Sayed, Yaser Y. ;

Quaintance, Cecele ;

Gibbs, Ronald ;

Darmstadt, Gary L. ;

Shaw, Gary M. ;

Stevenson, David K. ;

Tibshirani, Robert ;

Nolan, Garry P. ;

Lewis, David B. ;

Angst, Martin S. ;

Gaudilliere, Brice .

SCIENCE IMMUNOLOGY, 2017, 2 (15)

[4] Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans [J].

Alter, Galit ;

Yu, Jingyou ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Borducchi, Erica N. ;

Tostanoski, Lisa H. ;

McMahan, Katherine ;

Jacob-Dolan, Catherine ;

Martinez, David R. ;

Chang, Aiquan ;

Anioke, Tochi ;

Lifton, Michelle ;

Nkolola, Joseph ;

Stephenson, Kathryn E. ;

Atyeo, Caroline ;

Shin, Sally ;

Fields, Paul ;

Kaplan, Ian ;

Robins, Harlan ;

Amanat, Fatima ;

Krammer, Florian ;

Baric, Ralph S. ;

Le Gars, Mathieu ;

Sadoff, Jerald ;

de Groot, Anne Marit ;

Heerwegh, Dirk ;

Struyf, Frank ;

Douoguih, Macaya ;

van Hoof, Johan ;

Schuitemaker, Hanneke ;

Barouch, Dan H. .

NATURE, 2021, 596 (7871) :268-+

[5]

American College of Obstetricians and Gynecologists , 2021, COVID 19 VACC CONS O

[6]

[Anonymous], 2011, Updated Recommendations for Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine (Tdap) in Pregnant Women and Persons Who Have or Anticipate Having Close Contact with an Infant Aged lt

[7]

12 Months Advisory Committee on Immunization Practices (ACIP)

[8]

[Anonymous], 2021, JOHNSON JOHNSON ANNO

[9]

[Anonymous], 2019, C D C VACCINATING PR

[10] COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women [J].

Atyeo, Caroline ;

DeRiso, Elizabeth A. ;

Davis, Christine ;

Bordt, Evan A. ;

De Guzman, Rose M. ;

Shook, Lydia L. ;

Yonker, Lael M. ;

Fasano, Alessio ;

Akinwunmi, Babatunde ;

Lauffenburger, Douglas A. ;

Elovitz, Michal A. ;

Gray, Kathryn J. ;

Edlow, Andrea G. ;

Alter, Galit .

SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (617)

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