Target-specific deep brain stimulation of the ventral capsule/ventral striatum for the treatment of neuropsychiatric disease

被引:8
|
作者
Zhang, Chencheng [1 ]
Li, Dianyou [1 ]
Jin, Haiyan [2 ]
Zeljic, Kristina [3 ]
Sun, Bomin [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Funct Neurosurg, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Psychiat, Shanghai 200025, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China
基金
中国国家自然科学基金;
关键词
Deep brain stimulation (DBS); nucleus accumbens (NAc); ventral striatum (VS); obsessive-compulsive disorder (OCD); addiction; anorexia nervosa; OBSESSIVE-COMPULSIVE DISORDER; ANTERIOR CAPSULOTOMY; MAJOR DEPRESSION; LONG; VOLUME; DBS;
D O I
10.21037/atm.2017.07.13
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC). This VC/VS-specific electrode has the potential to enhance stimulus intensity, provide independent and flexible target stimulation.
引用
收藏
页数:6
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