Enantioselective cis-β-lactam synthesis by intramolecular C-H functionalization from enoldiazoacetamides and derivative donor-acceptor cyclopropenes

被引：76

作者：

Xu, Xinfang ^{[1
]}

Deng, Yongming ^{[2
]}

Yim, David N. ^{[2
]}

Zavalij, Peter Y. ^{[2
]}

Doyle, Michael P. ^{[2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

CHEMICAL SCIENCE | 2015年 / 6卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CHIRAL DIRHODIUM(II) CARBOXYLATES; CATALYZED ASYMMETRIC-SYNTHESIS; ALKYL-ALPHA-DIAZOESTERS; INSERTION REACTIONS; METAL-CARBENE; AMINO-ACIDS; RH(II)-CATALYZED CYCLOPROPANATION; DIAZO-COMPOUNDS; ENOL ETHERS; DIAZOACETAMIDES;

D O I：

10.1039/c4sc03991b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

beta-Lactam derivatives are produced through intermediate donor-acceptor cyclopropene intermediates in high yield, exclusive cis-diastereoselectivity, and high enantiocontrol in a chiral dirhodium carboxylate catalyzed intramolecular C-H functionalization reaction of enoldiazoacetamides.

引用

页码：2196 / 2201

页数：6

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