Immune modulation by MANF promotes tissue repair and regenerative success in the retina

被引：195

作者：

Neves, Joana ^{[1
]}

Zhu, Jie ^{[1
]}

Sousa-Victor, Pedro ^{[1
]}

Konjikusic, Mia ^{[1
]}

Riley, Rebeccah ^{[1
]}

Chew, Shereen ^{[1
]}

Qi, Yanyan ^{[1
]}

Jasper, Heinrich ^{[1
]}

Lamba, Deepak A. ^{[1
]}

机构：

[1] Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA

来源：

SCIENCE | 2016年 / 353卷 / 6294期

关键词：

NEUROTROPHIC FACTOR; MICROGLIAL ACTIVATION; BLOOD-CELLS; DROSOPHILA; DEGENERATION; MACROPHAGES; MOUSE; SURVIVAL; DNA; DIFFERENTIATION;

D O I：

10.1126/science.aaf3646

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regenerative therapies are limited by unfavorable environments in aging and diseased tissues. A promising strategy to improve success is to balance inflammatory and anti-inflammatory signals and enhance endogenous tissue repair mechanisms. Here, we identified a conserved immune modulatory mechanism that governs the interaction between damaged retinal cells and immune cells to promote tissue repair. In damaged retina of flies and mice, platelet-derived growth factor (PDGF)-like signaling induced mesencephalic astrocyte-derived neurotrophic factor (MANF) in innate immune cells. MANF promoted alternative activation of innate immune cells, enhanced neuroprotection and tissue repair, and improved the success of photoreceptor replacement therapies. Thus, immune modulation is required during tissue repair and regeneration. This approach may improve the efficacy of stem-cell-based regenerative therapies.

引用

页数：10

共 78 条

[1] Drosophila KDEL Receptor Function in the Embryonic Salivary Gland and Epidermis [J].

Abrams, Elliott W. ;

Cheng, Yim Ling ;

Andrew, Deborah J. .

PLOS ONE, 2013, 8 (10)

[2] Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior [J].

Auffray, Cedric ;

Fogg, Darin ;

Garfa, Meriem ;

Elain, Gaelle ;

Join-Lambert, Olivier ;

Kayal, Samer ;

Sarnacki, Sabine ;

Cumano, Ana ;

Lauvau, Gregoire ;

Geissmann, Frederic .

SCIENCE, 2007, 317 (5838) :666-670

[3] Immune Modulation of Stem Cells and Regeneration [J].

Aurora, Arin B. ;

Olson, Eric N. .

CELL STEM CELL, 2014, 15 (01) :15-26

[4] Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae [J].

Babcock, Daniel T. ;

Brock, Amanda R. ;

Fish, Greg S. ;

Wang, Yan ;

Perrin, Laurent ;

Krasnow, Mark A. ;

Galko, Michael J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (29) :10017-10022

[5] Repair of the degenerate retina by photoreceptor transplantation [J].

Barber, Amanda C. ;

Hippert, Claire ;

Duran, Yanai ;

West, Emma L. ;

Bainbridge, James W. B. ;

Warre-Cornish, Katherine ;

Luhmann, Ulrich F. O. ;

Lakowski, Jorn ;

Sowden, Jane C. ;

Ali, Robin R. ;

Pearson, Rachael A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (01) :354-359

[6] Drosophila as a Model of Wound Healing and Tissue Regeneration in Vertebrates [J].

Belacortu, Yaiza ;

Paricio, Nuria .

DEVELOPMENTAL DYNAMICS, 2011, 240 (11) :2379-2404

[7] Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation [J].

Cailhier, JF ;

Partolina, M ;

Vuthoori, S ;

Wu, SJ ;

Ko, K ;

Watson, S ;

Savill, J ;

Hughes, J ;

Lang, RA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :2336-2342

[8] Macrophage polarization in the maculae of age-related macular degeneration: A pilot study [J].

Cao, Xiaoguang ;

Shen, Defen ;

Patel, Mrinali M. ;

Tuo, Jingsheng ;

Johnson, T. Mark ;

Olsen, Timothy W. ;

Chan, Chi-Chao .

PATHOLOGY INTERNATIONAL, 2011, 61 (09) :528-535

[9] Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway [J].

Chen, Lijian ;

Feng, Lijie ;

Wang, Xia ;

Du, Jian ;

Chen, Ying ;

Yang, Wen ;

Zhou, Chengyue ;

Cheng, Li ;

Shen, Yujun ;

Fang, Shengyun ;

Li, Jun ;

Shen, Yuxian .

SCIENTIFIC REPORTS, 2015, 5

[10] Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation [J].

Chen, Mei ;

Luo, Chang ;

Penalva, Rosana ;

Xu, Heping .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (01) :682-690

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