Temporal Trends in Neurodevelopmental Outcomes to 2 Years After Extremely Preterm Birth

被引:75
作者
Cheong, Jeanie L. Y. [1 ,2 ,3 ]
Olsen, Joy E. [1 ,2 ]
Lee, Katherine J. [4 ,5 ]
Spittle, Alicia J. [1 ,2 ,6 ]
Opie, Gillian F. [3 ,7 ]
Clark, Marissa [8 ]
Boland, Rosemarie A. [2 ,3 ,9 ,10 ]
Roberts, Gehan [4 ,11 ,12 ]
Josev, Elisha K. [2 ,4 ,7 ]
Davis, Noni [1 ]
Hickey, Leah M. [2 ,4 ,13 ]
Anderson, Peter J. [2 ,14 ]
Doyle, Lex W. [1 ,2 ,3 ,4 ]
机构
[1] Royal Womens Hosp, Neonatal Serv, Melbourne, Vic, Australia
[2] Murdoch Childrens Res Inst, Clin Sci, Melbourne, Vic, Australia
[3] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia
[4] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[5] Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
[6] Univ Melbourne, Dept Physiotherapy, Melbourne, Vic, Australia
[7] Mercy Hosp Women, Neonatal Serv, Melbourne, Vic, Australia
[8] Monash Med Ctr, Dept Neonatol, Melbourne, Vic, Australia
[9] Univ Melbourne, Dept Nursing, Melbourne, Vic, Australia
[10] Royal Childrens Hosp, Paediat Infant Perinatal Emergency Retrieval, Melbourne, Vic, Australia
[11] Royal Childrens Hosp, Ctr Community & Child Hlth, Melbourne, Vic, Australia
[12] Murdoch Childrens Res Inst, Populat Hlth, Melbourne, Vic, Australia
[13] Royal Childrens Hosp, Neonatal Med, Melbourne, Vic, Australia
[14] Monash Univ, Monash Inst Cognit & Clin Neurosci, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
NEONATAL INTENSIVE-CARE; BAYLEY-III; OXYGEN-SATURATION; INFANTS; CHILDREN; WEIGHT; DELAY;
D O I
10.1001/jamapediatrics.2021.2052
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
IMPORTANCE Survival of infants born extremely preterm (EP) (<28 weeks' gestation) has increased since the early 1990s. It is necessary to know whether increased survival is accompanied by increased neurodevelopmental disability. OBJECTIVE To examine changes in major (ie, moderate or severe) neurodevelopmental disability and survival free of major neurodevelopmental disability at 2 years in infants born EP. DESIGN, SETTING, AND PARTICIPANTS Four prospective longitudinal cohort studies comprising all EP live births at 22 to 27 weeks' gestation from April 1, 2016, to March 31, 2017, and earlier eras (1991-1992, 1997, and 2005), and contemporaneous term-born controls in the state of Victoria, Australia. Among 1208 live births during the periods studied, data were available for analysis of 2-year outcomes in 1152 children: 422 (1991-1992), 215 (1997), 263 (2005), and 252 (2016-2017). Data analysis was performed from September 17, 2020, to April 15, 2021. EXPOSURES Extreme preterm live birth. MAIN OUTCOMES AND MEASURES Survival, blindness, deafness, cerebral palsy, developmental delay, and neurodevelopmental disability at 2 years' corrected age. Developmental delay comprised a developmental quotient less than -1 SD relative to the control group means on the Bayley Scales for each era. Major neurodevelopmental disability comprised blindness, deafness, moderate to severe cerebral palsy, or a developmental quotient less than -2 SDs. Individual neurodevelopmental outcomes in each era were contrasted relative to the 2016-2017 cohort using logistic regression adjusted for gestational age, sex, birth weight z score, and sociodemographic variables. Changes in survival free of major neurodevelopmental disability over time were also assessed using logistic regression. RESULTS Survival to 2 years was highest in 2016-2017 (73%[215 of 293]) compared with earlier eras (1991-1992: 53%[225 of 428]; 1997: 70% [151 of 217]; 2005: 63%[170 of 270]). Blindness and deafness were uncommon (<3%). Cerebral palsy was less common in 2016-2017 (6%) than in earlier eras (1991-1992: 11%; 1997: 12%; 2005: 10%). There were no obvious changes in the rates of developmental quotient less than -2 SDs across eras (1991-1992: 18%; 1997: 22%; 2005: 7%; 2016-2017: 15%) or in rates of major neurodevelopmental disability (1991-1992: 20%; 1997: 26%; 2005: 15%; 2016-2017: 15%). Rates of survival free of major neurodevelopmental disability increased steadily over time: 42%(1991-1992), 51%(1997), 53%(2005), and 62%(2016-2017) (odds ratio, 1.30; 95% CI, 1.15-1.48 per decade; P<.001). CONCLUSIONS AND RELEVANCE These findings suggest that survival free of major disability at age 2 years in children born EP has increased by an absolute 20% since the early 1990s. Increased survival has not been associated with increased neurodevelopmental disability.
引用
收藏
页码:1035 / 1042
页数:8
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