Emergence of a New Lineage of Dengue Virus Type 2 Identified in Travelers Entering Western Australia from Indonesia, 2010-2012

被引：33

作者：

Ernst, Timo ^{[1
]}

McCarthy, Suzi ^{[2
]}

Chidlow, Glenys ^{[2
]}

Luang-Suarkia, Dagwin ^{[1
,3
]}

Holmes, Edward C. ^{[4
,5
]}

Smith, David W. ^{[1
,2
]}

Imrie, Allison ^{[1
,2
]}

机构：

[1] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia

[2] PathWest Lab Med WA, Nedlands, WA, Australia

[3] Papua New Guinea Inst Med Res, Goroka, Papua N Guinea

[4] Univ Sydney, Sch Biol Sci, Charles Perkins Ctr, Marie Bashir Inst Emerging Dis & Biosecur, Sydney, NSW 2006, Australia

[5] Univ Sydney, Sch Med, Sydney, NSW 2006, Australia

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2015年 / 9卷 / 01期

基金：

英国医学研究理事会;

关键词：

HEMORRHAGIC-FEVER; EVOLUTION; PACIFIC; STRAINS; HAWAII;

D O I：

10.1371/journal.pntd.0003442

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Dengue virus (DENV) transmission is ubiquitous throughout the tropics. More than 70% of the current global dengue disease burden is borne by people who live in the Asia-Pacific region. We sequenced the E gene of DENV isolated from travellers entering Western Australia between 2010-2012, most of whom visited Indonesia, and identified a diverse array of DENV1-4, including multiple co-circulating viral lineages. Most viruses were closely related to lineages known to have circulated in Indonesia for some time, indicating that this geographic region serves as a major hub for dengue genetic diversity. Most notably, we identified a new lineage of DENV-2 (Cosmopolitan genotype) that emerged in Bali in 2011-2012. The spread of this lineage should clearly be monitored. Surveillance of symptomatic returned travellers provides important and timely information on circulating DENV serotypes and genotypes, and can reveal the herald wave of dengue and other emerging infectious diseases.

引用

页数：15

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