Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases

被引：130

作者：

Quintana-Murci, Lluis

Alcais, Alexandre

Abel, Laurent

Casanova, Jean-Laurent ^{[1
]}

机构：

[1] Necker Med Sch, INSERM, Lab Human Genet Infect Dis, U550, F-75015 Paris, France

[2] Inst Pasteur, CNRS, URA3012, Human Evolutionary Genet Unit, F-75015 Paris, France

[3] Univ Paris 05, Necker Med Sch, F-75015 Paris, France

[4] Necker Childrens Hosp, Pediat Hematol & Immunol Unit, F-75015 Paris, France

来源：

NATURE IMMUNOLOGY | 2007年 / 8卷 / 11期

关键词：

D O I：

10.1038/ni1535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The field of human genetics of infectious diseases defines the genes and alleles rendering individuals (clinical genetics) and populations (epidemiological genetics) vulnerable to infection, and studies those selected by previous infections (evolutionary genetics). These disciplines - clinical, epidemiological and evolutionary genetics - delineate the redundant and nonredundant functions of host defense genes for past and present survival in natura - in natural ecosystems governed by natural selection. These disciplines, in other words, assess the ecologically relevant and evolutionarily selected roles of human genes and alleles in protective immunity to diverse and evolving microorganisms. The genetic dissection of human immunity to infection in natura provides unique immunological insight, making it an indispensable complement to experimental immunology in vitro and in vivo in plants and animals.

引用

页码：1165 / 1171

页数：7

共 100 条

[91] DISRUPTION OF A GATA MOTIF IN THE DUFFY GENE PROMOTER ABOLISHES ERYTHROID GENE-EXPRESSION IN DUFFY NEGATIVE INDIVIDUALS [J].

TOURNAMILLE, C ;

COLIN, Y ;

CARTRON, JP ;

LEVANKIM, C .

NATURE GENETICS, 1995, 10 (02) :224-228

[92] Positive selection on the human genome [J].

Vallender, EJ ;

Lahn, BT .

HUMAN MOLECULAR GENETICS, 2004, 13 :R245-R254

[93]

VALLERYRADOT R, 1926, LIFE PASTEUR, V21

[94] Brief report:: Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I [J].

Vanhollebeke, Benoit ;

Truc, Philippe ;

Poelvoorde, Philippe ;

Pays, Annette ;

Joshi, Prashant P. ;

Katti, Ravindra ;

Jannin, Jean G. ;

Pays, Etienne .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (26) :2752-2756

[95] Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles [J].

Verdu, Paul ;

Barreiro, Luis B. ;

Patin, Etienne ;

Gessain, Antoine ;

Cassar, Olivier ;

Kidd, Judith R. ;

Kidd, Kenneth K. ;

Behar, Doron M. ;

Froment, Alain ;

Heyer, Evelyne ;

Sica, Lucas ;

Casanova, Jean-Laurent ;

Abel, Laurent ;

Quintana-Murci, Lluis .

HUMAN MOLECULAR GENETICS, 2006, 15 (17) :2650-2658

[96] Human red blood cell polymorphisms and malaria [J].

Williams, Thomas N. .

CURRENT OPINION IN MICROBIOLOGY, 2006, 9 (04) :388-394

[97] Spread of an inactive form of caspase-12 in humans is due to recent positive selection [J].

Xue, YL ;

Daly, A ;

Yngvadottir, B ;

Liu, MN ;

Coop, G ;

Kim, Y ;

Sabeti, P ;

Chen, Y ;

Stalker, J ;

Huckle, E ;

Burton, J ;

Leonard, S ;

Rogers, J ;

Tyler-Smith, C .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (04) :659-670

[98] Human TLR-7-,-8-, and -9-mediated induction of IFN-α/β and -λ is IRAK-4 dependent and redundant for protective immunity to viruses [J].

Yang, K ;

Puel, A ;

Zhang, SY ;

Eidenschenk, C ;

Ku, CL ;

Casrouge, A ;

Picard, C ;

von Bernuth, H ;

Senechal, B ;

Plancoulaine, S ;

Al-Hajjar, S ;

Al-Ghonaium, A ;

Maródi, L ;

Davidson, D ;

Speert, D ;

Roifman, C ;

Garty, BZ ;

Ozinsky, A ;

Barrat, FJ ;

Coffman, RL ;

Miller, RL ;

Li, XX ;

Lebon, P ;

Rodriguez-Gallego, C ;

Chapel, H ;

Geissmann, F ;

Jouanguy, E ;

Casanova, JL .

IMMUNITY, 2005, 23 (05) :465-478

[99] Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function [J].

Yawata, M ;

Yawata, N ;

Draghi, M ;

Little, AM ;

Partheniou, F ;

Parham, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (03) :633-645

[100] TLR3 deficiency in patients with herpes simplex encephalitis [J].

Zhang, Shen-Ying ;

Jouanguy, Emmanuelle ;

Ugolini, Sophie ;

Smahi, Asma ;

Elain, Gaelle ;

Romero, Pedro ;

Segal, David ;

Sancho-Shimizu, Vanessa ;

Lorenzo, Lazaro ;

Puel, Anne ;

Picard, Capucine ;

Chapgier, Ariane ;

Plancoulaine, Sabine ;

Titeux, Matthias ;

Cognet, Celine ;

von Bernuth, Horst ;

Ku, Cheng-Lung ;

Casrouge, Armanda ;

Zhang, Xin-Xin ;

Barreiro, Luis ;

Leonard, Joshua ;

Hamilton, Claire ;

Lebon, Pierre ;

Heron, Benedicte ;

Vallee, Louis ;

Quintana-Murci, Lluis ;

Hovnanian, Alain ;

Rozenberg, Flore ;

Vivier, Eric ;

Geissmann, Frederic ;

Tardieu, Marc ;

Abel, Laurent ;

Casanova, Jean-Laurent .

SCIENCE, 2007, 317 (5844) :1522-1527

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