Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases

被引：129
作者：
Quintana-Murci, Lluis
Alcais, Alexandre
Abel, Laurent
Casanova, Jean-Laurent [1 ]
机构：
[1] Necker Med Sch, INSERM, Lab Human Genet Infect Dis, U550, F-75015 Paris, France
[2] Inst Pasteur, CNRS, URA3012, Human Evolutionary Genet Unit, F-75015 Paris, France
[3] Univ Paris 05, Necker Med Sch, F-75015 Paris, France
[4] Necker Childrens Hosp, Pediat Hematol & Immunol Unit, F-75015 Paris, France
来源：
NATURE IMMUNOLOGY | 2007年 / 8卷 / 11期
关键词：
D O I：
10.1038/ni1535
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The field of human genetics of infectious diseases defines the genes and alleles rendering individuals (clinical genetics) and populations (epidemiological genetics) vulnerable to infection, and studies those selected by previous infections (evolutionary genetics). These disciplines - clinical, epidemiological and evolutionary genetics - delineate the redundant and nonredundant functions of host defense genes for past and present survival in natura - in natural ecosystems governed by natural selection. These disciplines, in other words, assess the ecologically relevant and evolutionarily selected roles of human genes and alleles in protective immunity to diverse and evolving microorganisms. The genetic dissection of human immunity to infection in natura provides unique immunological insight, making it an indispensable complement to experimental immunology in vitro and in vivo in plants and animals.
引用
收藏
页码：1165 / 1171
页数：7
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