Involvement of MTHFR rs1801133 in the Susceptibility of Acute Lymphoblastic Leukemia: A Preliminary Study

被引：4

作者：

Frikha, Rim ^{[1
]}

Turki, Fatma ^{[1
]}

Frikha, Fakher ^{[2
]}

Elloumi, Moez ^{[3
]}

Rebai, Tarek ^{[1
]}

机构：

[1] Univ Sfax, Histol Lab, Fac Med Sfax, Sfax, Tunisia

[2] Univ Sfax, Fac Sci Sfax, Sfax, Tunisia

[3] Hedi Chaker Univ Teaching Hosp, Dept Haematol, Sfax, Tunisia

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2021年 / 43卷 / 06期

关键词：

MTHFR; rs1801133; association; acute lymphoblastic leukemia; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; GENETIC RISK-FACTOR; POLYMORPHISM; CHILDREN; PATHWAY; LEIDEN;

D O I：

10.1097/MPH.0000000000001970

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Acute lymphoblastic leukemia (ALL), a common blood cancer, is characterized by the interaction between genetic and environmental factors. Several variants of the Methylenetetrahydrofolate reductase (MTHFR), mainly the C677T (rs1801133), may affect susceptibility to ALL. Aim of the Study: The authors conducted this case-control study to evaluate the relationship between this variant of the MTHFR gene and the risk of ALL. Materials and Methods: Forty-one patients with ALL and 35 non-ALL controls recruited in this study were genotyped utilizing polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The MTHFR 677CT genotype was significantly more frequently found in patients with ALL having a 2-fold increase in risk (P <0.01). Conclusion: Our results suggest that rs1801133 of MTHFR is a predictive risk marker to ALL in Tunisian ALL.

引用

收藏

页码：E816 / E818

页数：3

相关论文

共 31 条

[1] 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children [J].

Alcasabas, Patricia ;

Ravindranath, Yaddanapudi ;

Goyette, Gerard ;

Haller, Andrew ;

del Rosario, Luz ;

Lesaca-Medina, Maria Ysabel ;

Darga, Linda ;

Ostrea, Enrique M., Jr. ;

Taub, Jeffrey W. ;

Everson, Richard B. .

PEDIATRIC BLOOD & CANCER, 2008, 51 (02) :178-182

[2] An Arab selective gradient in the distribution of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T [J].

Ameen, G ;

Irani-Hakime, N ;

Fawaz, NA ;

Mahjoub, T ;

Almawi, WY .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (09) :2126-2127

[3] Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE) [J].

Amigou, Alicia ;

Rudant, Jeremie ;

Orsi, Laurent ;

Goujon-Bellec, Stephanie ;

Leverger, Guy ;

Baruchel, Andre ;

Bertrand, Yves ;

Nelken, Brigitte ;

Plat, Genevieve ;

Michel, Gerard ;

Haouy, Stephanie ;

Chastagner, Pascal ;

Ducassou, Stephane ;

Rialland, Xavier ;

Hemon, Denis ;

Clavel, Jacqueline .

CANCER CAUSES & CONTROL, 2012, 23 (08) :1265-1277

[4] The Prevalence of Methylenetetrahydrofolate Reductase 677 C-T, Factor V 1691 G-A, and Prothrombin 20210 G-A Mutations in Healthy Populations in Setif, Algeria [J].

Bourouba, Romyla ;

Houcher, Bakhouche ;

Djabi, Farida ;

Egin, Yonca ;

Akar, Nejat .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2009, 15 (05) :529-534

[5] 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation [J].

Castro, R ;

Rivera, I ;

Ravasco, P ;

Camilo, ME ;

Jakobs, C ;

Blom, HJ ;

de Almeida, IT .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (06) :454-458

[6] Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Java']Javanese children [J].

Chan, Jason Yong-Sheng ;

Ugrasena, Dewa G. ;

Lum, Danny Wai-Kiong ;

Lu, Yi ;

Yeoh, Allen Eng-Juh .

HEMATOLOGICAL ONCOLOGY, 2011, 29 (03) :116-123

[7] Methylenetetrahydrofolate reductase C677T polymorphism: Association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in Greek patients [J].

Chatzidakis, Konstantinos ;

Goulas, Antonis ;

Athanassiadou-Piperopoulou, Fani ;

Fidani, Liana ;

Koliouskas, Dirnitrios ;

Mirtsou, Vassiliki .

PEDIATRIC BLOOD & CANCER, 2006, 47 (02) :147-151

[8] Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis [J].

Frikha, Rim .

JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2020, 26 (07) :1598-1610

[9] A duplex polymerase chain reaction-restriction fragment length polymorphism for rapid screening of methylenetetrahydrofolate reductase gene variants: Genotyping in acute leukemia [J].

Frikha, Rim ;

Bouayed, Nouha ;

Ben Rhouma, Bochra ;

Keskes, Leila ;

Rebai, Tarek .

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2018, 32 (01)

[10] A CANDIDATE GENETIC RISK FACTOR FOR VASCULAR-DISEASE - A COMMON MUTATION IN METHYLENETETRAHYDROFOLATE REDUCTASE [J].

FROSST, P ;

BLOM, HJ ;

MILOS, R ;

GOYETTE, P ;

SHEPPARD, CA ;

MATTHEWS, RG ;

BOERS, GJH ;

DENHEIJER, M ;

KLUIJTMANS, LAJ ;

VANDENHEUVEL, LP ;

ROZEN, R .

NATURE GENETICS, 1995, 10 (01) :111-113

← 1 2 3 4 →