Roles of Fibroblast Growth Factor Receptors in Carcinogenesis

被引：261

作者：

Haugsten, Ellen Margrethe ^{[1
]}

Wiedlocha, Antoni

Olsnes, Sjur

Wesche, Jorgen ^{[1
]}

机构：

[1] Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, N-0310 Oslo, Norway

来源：

MOLECULAR CANCER RESEARCH | 2010年 / 8卷 / 11期

关键词：

8P11 MYELOPROLIFERATIVE SYNDROME; HUMAN BREAST-CANCER; FGFR4 GLY388ARG POLYMORPHISM; SQUAMOUS-CELL CARCINOMA; HUMAN GLIOBLASTOMA-MULTIFORME; POTENTIAL THERAPEUTIC TARGET; LETHAL SKELETAL DYSPLASIA; MAMMARY-GLAND DEVELOPMENT; MULTIPLE-MYELOMA PATIENTS; GENOME-WIDE ASSOCIATION;

D O I：

10.1158/1541-7786.MCR-10-0168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression. Mol Cancer Res; 8(11); 1439-52. (C) 2010 AACR.

引用

页码：1439 / 1452

页数：14

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