Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients

被引：8

作者：

Kundrapu, Sirisha ^{[1
]}

Hurless, Kelly ^{[1
]}

Sunkesula, Venkata C. K. ^{[1
]}

Tomas, Myreen ^{[1
,2
]}

Donskey, Curtis J. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Med, Div Infect Dis, Cleveland, OH 44106 USA

[2] Cleveland VA Med Ctr, Geriatr Res Educ & Clin Ctr, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2015年 / 45卷 / 04期

关键词：

Inhibition; Clostridium difficile; Tigecycline;

D O I：

10.1016/j.ijantimicag.2014.11.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

No new acquisition of Clostridium difficile occurred among 12 hospitalised patients receiving tigecycline, and pre-existing colonisation was reduced to undetectable levels in 2 patients. Moreover, 91% of stool suspensions obtained during tigecycline therapy exhibited inhibitory activity against C. difficile. These results suggest that tigecycline achieves sufficient concentrations to inhibit intestinal colonisation by C difficile. Published by Elsevier B.V. on behalf of International Society of Chemotherapy

引用

页码：424 / 426

页数：3

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