Kappa free light chains index in the differential diagnosis of Multiple Sclerosis from Neuromyelitis optica spectrum disorders and other immune-mediated central nervous system disorders

被引：28

作者：

Cavalla, P. ^{[1
]}

Caropreso, P. ^{[2
]}

Limoncelli, S. ^{[2
]}

Bosa, C. ^{[1
]}

Pasanisi, M. B. ^{[1
]}

Schillaci, V ^{[1
]}

Alteno, A. ^{[1
]}

Costantini, G. ^{[1
]}

Giordana, M. T. ^{[1
]}

Mengozzi, G. ^{[2
]}

Vercellino, M. ^{[1
]}

机构：

[1] AOU Citta Salute & Sci Torino, Dept Neurosci, Neurol IU, Turin, Italy

[2] AOU Citta Salute & Sci Torino, Clin Biochem Lab, Dept Lab Med, Turin, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 339卷

关键词：

Multiple sclerosis; Cerebrospinal fluid; Oligoclonal bands; Free light chains; K index; Isoelectrofocusing; CEREBROSPINAL-FLUID; OLIGOCLONAL IGG; KFLC; CSF;

D O I：

10.1016/j.jneuroim.2019.577122

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The K free light chains index (K-FLC index) has been proposed as an alternative test for intrathecal immunoglobulin synthesis in MS diagnosis. Aim of the study was to assess the accuracy of the K-FLC index in differentiating MS from other immune-mediated CNS disorders and NMOSD. Data were available from a cohort of 371 patients. K-FLC index was significantly higher in MS: MS mean K-FLC index 90.897 +/- 134.198; NMOSD 17.992 +/- 15.103; other immune-mediated CNS disorders 12.568 +/- 24.440. The overall diagnostic accuracy of the K-FLC index was similar to intrathecal oligoclonal bands detection. However, as a quantitative variable, K-FLC index allowed easier discrimination of MS from other immune-mediated CNS disorders: highest K-FLC index values (> 100) were observed almost only in MS and are therefore strongly predictive of MS, in patients with the appropriate clinical presentation.

引用

页数：6

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