Yasutomi Nishizuka: Father of protein kinase C

被引:14
作者
Nakamura, Shun-ichi [2 ]
Yamamura, Hirohei [1 ]
机构
[1] Hyogo Prefectural Inst Publ Hlth & Consumer Sci, Kobe, Hyogo 6520032, Japan
[2] Kobe Univ, Div Biochem, Grad Sch Med, Kobe, Hyogo 6500017, Japan
关键词
diacylglycerol; inositol turnover; lipid mediators; phorbol ester; protein kinase C;
D O I
10.1093/jb/mvq066
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is 6 years since we received the tragic news that our great mentor Dr Yasutomi Nishizuka passed away suddenly at the age of 72 years. Dr Nishizuka made several epoch-making discoveries in his life, e.g. the tryptophan metabolism, protein synthesis, ADP-ribosylation, regulation of cAMP-dependent protein kinase and discovery of protein kinase C (PKC). Among them his name will be remembered for a long time as a father of PKC, momentous discoveries in the twentieth century, which are still actively pursued by many laboratories worldwide.
引用
收藏
页码:125 / 130
页数:6
相关论文
共 39 条
[1]  
Nishizuka Y., Takeshita M., Kuno S., Hayaishi O., B-Alanine-alanine transaminase of Pseudomonas, Biochim. Biophys. Acta, 33, pp. 591-593, (1959)
[2]  
Nishizuka Y., Hayaishi O., Studies on the biosynthesis of nicotinamide adenine dinucleotide. I. Enzymic synthesis of niacin ribonucleotides from 3-hydroxyanthranic acid in mammalian tissues, J. Biol. Chem., 238, pp. 3369-3377, (1963)
[3]  
Nishizuka Y., Lipmann F., The interrelationship between guanosine triphosphatase and amino acid polymerization, Arch. Biochem. Biophys., 116, pp. 344-351, (1966)
[4]  
Nishizuka Y., Ueda K., Nakazawa K., Hayaishi O., Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei, J. Biol. Chem., 242, pp. 3164-3171, (1967)
[5]  
Honjo T., Nishizuka Y., Hayaishi O., Kato I., Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis, J. Biol. Chem., 243, pp. 3553-3555, (1968)
[6]  
Walsh D.A., Perkins J.P., Krebs E.G., An adenosine 30,50-monophosphate-dependant protein kinase from rabbit skeletal muscle, J. Biol. Chem., 243, pp. 3763-3765, (1968)
[7]  
Yamamura H., Takeda M., Kumon A., Nishizuka Y., Adenosine 30,50-cyclic phosphate-dependent and independent histone kinases from rat liver, Biochem. Biophys. Res. Commun., 40, pp. 675-682, (1970)
[8]  
Kumon A., Yamamura H., Nishizuka Y., Mode of action of adenosine 30,50-cyclic phosphate on protein kinase from rat liver, Biochem. Biophys. Res. Commun., 41, pp. 1290-1297, (1970)
[9]  
Tao M., Salas M.L., Lipmann F., Mechanism of activation by adenosine 30 : 50-cyclic monophosphate of a protein phosphokinase from rabbit reticulocytes, Proc. Natl Acad. Sci. USA, 67, pp. 408-414, (1970)
[10]  
Gill G.N., Garren L.D., Role of the receptor in the mechanism of action of adenosine 30 : 50- cyclic monophosphate, Proc. Natl Acad. Sci. USA, 68, pp. 786-790, (1971)