Allogeneic bone marrow transplantation for refractory mantle cell lymphoma

被引：19
作者：
Kröger, N
Hoffknecht, M
Krüger, W
Zeller, W
Renges, H
Stute, N
Zschaber, R
Zander, AR
机构：
[1] Univ Hamburg, Hosp Eppendorf, Dept Bone Marrow Transplant, D-20246 Hamburg, Germany
[2] Univ Hamburg, Hosp Eppendorf, Dept Hematol Oncol, D-20246 Hamburg, Germany
来源：
ANNALS OF HEMATOLOGY | 2000年 / 79卷 / 10期
关键词：
low grade lymphoma; mantle-cell lymphoma; allogeneic bone marrow transplantation; graft versus lymphoma effect;
D O I：
10.1007/s002770000196
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, etoposide, and cyclophosphamide. The patient experienced hepatic toxicity (grade I), mucositis (grade II) according the Bearman scale, and graft versus host, disease of the skin (grade II) and showed stable engraftment with complete chimerism on day 15 after bone marrow transplantation. Eight years after transplantation, the patient is still disease free and in good condition without any late side effects. This report suggests a curative potential of allogeneic stem cell transplantation in MCL.
引用
收藏
页码：578 / 580
页数：3
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