Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

被引：47

作者：

Haller, Sebastian ^{[1
]}

Kramer, Rolf ^{[1
]}

Becker, Karsten ^{[5
]}

Bohnert, Juergen A. ^{[5
]}

Eckmanns, Tim ^{[1
]}

Hans, Joerg B. ^{[6
]}

Hecht, Jane ^{[1
]}

Heidecke, Claus-Dieter ^{[5
]}

Huebner, Nils-Olaf ^{[5
]}

Kramer, Axel ^{[5
]}

Klaper, Kathleen ^{[2
]}

Littmann, Martina ^{[4
]}

Marlinghaus, Lennart ^{[6
]}

Neumann, Bernd ^{[2
]}

Pfeifer, Yvonne ^{[2
]}

Pfennigwerth, Niels ^{[6
]}

Rogge, Simone ^{[4
]}

Schaufler, Katharina ^{[7
]}

Thuermer, Andrea ^{[3
]}

Werner, Guido ^{[2
]}

Gatermann, Soeren ^{[6
]}

机构：

[1] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany

[2] Robert Koch Inst, Div Nosocomial Pathogens & Antibiot Resistance, Wernigerode, Germany

[3] Robert Koch Inst, Genome Sequencing Unit, Berlin, Germany

[4] Reg Publ Hlth Author Mecklenburg Western Pomerani, Rostock, Germany

[5] Univ Med Greifswald, Greifswald, Germany

[6] Ruhr Univ Bochum, Natl Reference Ctr Multidrug Resistant Gram Negat, Bochum, Germany

[7] Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Greifswald, Germany

来源：

EUROSURVEILLANCE | 2019年 / 24卷 / 50期

关键词：

EMERGENCE;

D O I：

10.2807/1560-7917.ES.2019.24.50.1900734

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.

引用

页码：2 / 7

页数：6

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