A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

被引：19
作者：
Benkerrou, D. [1 ]
Minicozzi, V. [2 ,3 ]
Gradogna, A. [4 ]
Milenkovic, S. [1 ]
Bodrenko, I. V. [1 ,8 ]
Festa, M. [5 ]
Lagostena, L. [4 ]
Cornara, L. [6 ]
D'Amore, A. [7 ]
Ceccarelli, M. [1 ,8 ]
Filippini, A. [7 ]
Carpaneto, A. [4 ,6 ]
机构：
[1] Univ Cagliari, Dept Phys, I-09042 Monserrato, Italy
[2] Univ Roma Tor Vergata, INFN, Via Ric Sci 1, I-00133 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Phys, Via Ric Sci 1, I-00133 Rome, Italy
[4] CNR, Inst Biophys, Via De Marini 6, I-16149 Genoa, Italy
[5] Univ Padua, Dept Biol, Via U Bassi 58-b, I-35131 Padua, Italy
[6] Univ Genoa, Dept Earth Environm & Life Sci DISTAV, Viale Benedetto XV 5, I-16132 Genoa, Italy
[7] Sapienza Univ Rome, Unit Histol & Med Embryol, Dept Anat Histol Forens Med & Orthopaed, 16 Via A Scarpa, I-00161 Rome, Italy
[8] Cittadella Univ, Unita Cagliari, CNR, IOM, I-09042 Monserrato, Italy
来源：
BIOPHYSICAL CHEMISTRY | 2019年 / 254卷
关键词：
TPC channels; Plant vacuole; Animal lysosome; Patch-clamp; Fluorescence; Molecular docking; SLOWLY ACTIVATING CHANNELS; DEPENDENT ION CHANNELS; POTASSIUM CHANNEL; VACUOLAR CHANNEL; VOLTAGE; PROTOPLASTS; EXPRESSION; LIDOCAINE; TARGETS; SYSTEM;
D O I：
10.1016/j.bpc.2019.106246
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.
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页数：6
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