1,4-Naphthoquinones: Some Biological Properties and Application

被引：125
|
作者：
Aminin, Dmitry [1 ,2 ]
Polonik, Sergey [1 ]
机构：
[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Prospect 100 Let Vladivostoku 159, Vladivostok 690022, Russia
[2] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2020年 / 68卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
1,4-naphthoquinone; chemical structure; biological property; molecular target; NAPHTHOQUINONE DERIVATIVES; ANTICANCER ACTIVITIES; INHIBITORY-ACTIVITY; ECHINOCHROME; SHIKONIN; ANTIBACTERIAL; RECEPTOR; DIONCOQUINONES; TUBERCULOSIS; LAWSONE;
D O I：
10.1248/cpb.c19-00911
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, anti-ischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.
引用
收藏
页码：46 / 57
页数：12
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