1,4-Naphthoquinones: Some Biological Properties and Application

被引：133

作者：

Aminin, Dmitry ^{[1
,2
]}

Polonik, Sergey ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Prospect 100 Let Vladivostoku 159, Vladivostok 690022, Russia

[2] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2020年 / 68卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

1,4-naphthoquinone; chemical structure; biological property; molecular target; NAPHTHOQUINONE DERIVATIVES; ANTICANCER ACTIVITIES; INHIBITORY-ACTIVITY; ECHINOCHROME; SHIKONIN; ANTIBACTERIAL; RECEPTOR; DIONCOQUINONES; TUBERCULOSIS; LAWSONE;

D O I：

10.1248/cpb.c19-00911

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, anti-ischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.

引用

页码：46 / 57

页数：12

共 92 条

[1] Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography [J].