The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected gram-positive bacteria

被引：36
|
作者：
Irschik, Herbert
Reichenbach, Hans [1 ]
Hoefle, Gerhard [1 ]
Jansen, Rolf
机构：
[1] Helmholtz Zentrum Infekt Forsch, D-38124 Braunschweig, Germany
来源：
JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 12期
关键词：
Sorangium cellulosum; antibiotics; macrolides; respiration; thuggacin;
D O I：
10.1038/ja.2007.95
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In our screening program we found an activity against some Gram-positive bacteria, including mycobacteria in the culture supernatant of Sorangium cellulosum strain So ce895. The antibiotic responsible for this activity was isolated and named thuggacin. Initial studies towards the mechanism of action showed that thuggacin A inhibits a late step of the respiratory chain of some bacteria.
引用
收藏
页码：733 / 738
页数：6
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