First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA

被引：342

作者：

Ghinai, Isaac ^{[1
,7
]}

McPherson, Tristan D. ^{[1
,8
]}

Hunter, Jennifer C. ^{[2
]}

Kirking, Hannah L. ^{[3
]}

Christiansen, Demian ^{[9
]}

Joshi, Kiran ^{[9
]}

Rubin, Rachel ^{[9
]}

Morales-Estrada, Shirley ^{[9
]}

Black, Stephanie R. ^{[8
]}

Pacilli, Massimo ^{[8
]}

Fricchione, Marielle J. ^{[8
]}

Chugh, Rashmi K. ^{[10
]}

Walblay, Kelly A. ^{[8
]}

Ahmed, N. Seema ^{[11
]}

Stoecker, William C. ^{[11
]}

Hasan, Nausheen F. ^{[12
]}

Burdsall, Deborah P. ^{[7
]}

Reese, Heather E. ^{[1
,4
]}

Wallace, Megan ^{[1
,3
]}

Wang, Chen ^{[13
,14
]}

Moeller, Darcie ^{[13
,14
]}

Korpics, Jacqueline ^{[13
,14
]}

Novosad, Shannon A. ^{[2
]}

Benowitz, Isaac ^{[2
]}

Jacobs, Max W. ^{[5
,15
]}

Dasari, Vishal S. ^{[6
,16
]}

Patel, Megan T. ^{[7
]}

Kauerauf, Judy ^{[7
]}

Charles, E. Matt ^{[7
]}

Ezike, Ngozi O. ^{[7
]}

Chu, Victoria ^{[1
,3
]}

Midgley, Claire M. ^{[3
]}

Rolfes, Melissa A. ^{[5
]}

Gerber, Susan I. ^{[3
]}

Lu, Xiaoyan ^{[3
]}

Lindstrom, Stephen ^{[3
]}

Verani, Jennifer R. ^{[4
]}

Layden, Jennifer E. ^{[8
]}

机构：

[1] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA

[2] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA

[3] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[4] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[5] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[6] Ctr Dis Control & Prevent, One Hlth Off, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA

[7] Illinois Dept Publ Hlth, Springfield, IL 62761 USA

[8] Chicago Dept Publ Hlth, Chicago, IL USA

[9] Cook Cty Dept Publ Hlth, Oak Forest, IL USA

[10] DuPage Cty Hlth Dept, Wheaton, IL USA

[11] Metro Infect Dis Consultants, Burr Ridge, IL USA

[12] Premier Primary Care Phys, Carol Stream, IL USA

[13] Cook Cty Hlth, Chicago, IL USA

[14] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[15] Lake Erie Coll Osteopath Med, Erie, PA USA

[16] Wright State Univ, Boonshoft Sch Med, Dayton, OH 45435 USA

来源：

LANCET | 2020年 / 395卷 / 10230期

关键词：

D O I：

10.1016/S0140-6736(20)30607-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA. Methods Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient's symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested. Findings Patient 1-a woman in her 60s-returned from China in mid-January, 2020. 1 week later, she was hospitalised with pneumonia and tested positive for SARS-CoV- 2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2. Interpretation Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected.

引用

页码：1137 / 1144

页数：8

共 21 条

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