Human Induced Pluripotent Stem Cells: The Past, Present, and Future

被引：24
|
作者：
Hussein, S. M. I. [1 ]
Nagy, K. [1 ]
Nagy, A. [1 ,2 ]
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 05期
关键词：
HUMAN SOMATIC-CELLS; HUMAN FIBROBLASTS; INDUCTION; GENERATION; VECTOR; DIFFERENTIATION; EXCISION; VIRUS;
D O I：
10.1038/clpt.2011.37
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A major breakthrough in the past 5 years is the development of the ability to reprogram somatic cells to pluripotency. It has rejuvenated the field of stem cell research, providing regenerative medicine with new possibilities. In this paper, we discuss the progress made in the reprogramming field with focus on induction methodologies, the use of induced pluripotent stem cells (iPSCs) for drug discovery, and issues and precautions related to their use in regenerative medicine.
引用
收藏
页码：741 / 745
页数：5
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