Enantioselective addition of aldehydes to amines via combined catalytic biomimetic oxidation and organocatalytic C-C bond formation

被引：42

作者：

Ibrahem, I ^{[1
]}

Samec, JSM ^{[1
]}

Bäckvall, JE ^{[1
]}

Córdova, A ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 23期

关键词：

biomimetic oxidation; catalysis; asymmetric synthesis; ruthenium; proline;

D O I：

10.1016/j.tetlet.2005.04.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biomimetic catalytic enantioselective addition of aldehydes to amines is reported. This was accomplished by combining biomimetic coupled catalytic aerobic oxidation of amines involving ruthenium-induced dehydrogenation and organocatalytic asymmetric Mannich reactions. The novel one-pot reactions furnished beta-amino aldehyde and alpha-amino acid derivatives in high yields with excellent chemoselectivity and up to > 99% ee. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3965 / 3968

页数：4

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