Five Functional Aspects of the Epidermal Barrier

被引：76

作者：

Lefevre-Utile, Alain ^{[1
,2
]}

Braun, Camille ^{[3
,4
]}

Haftek, Marek ^{[5
]}

Aubin, Francois ^{[6
,7
]}

机构：

[1] Hop Jean Verdier, AP HP, Sce Pediat Gen & Urgence Pediat, F-93140 Bondy, France

[2] Univ Paris, Inst Rech St Louis, INSERM, Unite HIPI 976, F-75010 Paris, France

[3] Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, INSERM, U1111, F-69007 Lyon, France

[4] Hop Femme Mere Enfant, Sce Pneumol Pediat & Allergie, F-69500 Bron, France

[5] Lyon1 Univ, CNRS, UMR5305, Lab Tissue Biol & Therapeut Engn,LBTI, F-69100 Lyon, France

[6] Univ Franche Comte, INSERM, U1098, F-25000 Besancon, France

[7] CHU Besancon, Sce Dermatol, F-25000 Besancon, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

epidermis; skin barrier; stratum corneum; ceramides; keratinization; desmosomes; tight junctions; immunity; sensory nerves; microbiome; STRATUM-CORNEUM; TIGHT-JUNCTIONS; LAMELLAR BODIES; SKIN; MAINTENANCE; INVOLVEMENT; ENVELOPES; PROTEINS; LIPIDS;

D O I：

10.3390/ijms222111676

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epidermis is a living, multilayered barrier with five functional levels, including a physical, a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ contributes to protect the host from external aggression and to preserve its integrity. In this review, we focused on the different functional aspects.

引用

页数：14

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