Tautomeric changes in guanfacine and its copper(II) complex as revealed by X-ray crystallography; synthesis and EPR

被引：6
|
作者：
Tomas, A
Viossat, B
Charlot, MF
Girerd, JJ
Huy, DN
机构：
[1] Fac Pharm, UMR 8015, Lab Cristallog & RMN Biol, F-75270 Paris, France
[2] Univ Paris 11, Chim Inorgan Lab, UMR 8613, F-91405 Orsay, France
[3] Lab Cristallochim Bioinorgan, F-92296 Chatenay Malabry, France
来源：
INORGANICA CHIMICA ACTA | 2005年 / 358卷 / 11期
关键词：
copper(II) complex; crystal structure; EPR analysis; guanfacine; tautomeric forms;
D O I：
10.1016/j.ica.2005.03.040
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Obtention and crystal structure of guanfacine (guaH) together with synthesis and crystal structure of its copper complex [Cu-II(gua)(2)] center dot DMF were reported. The free molecule guaH exhibits one tautomeric form (B) in contrast to the form (A) which was reported in the Merck index. In the copper(II) complex, the anionic form gua(-) exhibits the third tautomeric form (C). This complex is characterized by a CuN2O2 coordination. The EPR spectrum is in agreement with a Cu(II) ion in a square planar configuration. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：3253 / 3258
页数：6
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