Synthesis of phosphorylated derivatives of isatin with sterically hindered phenol fragments

被引：1

作者：

Bukharov, Sergey V. ^{[1
]}

Burilov, Alexander R. ^{[2
]}

Oludina, Yulia N. ^{[1
]}

Tagasheva, Roza G. ^{[1
]}

Syakaev, Viktor V. ^{[2
]}

Musin, Rashid Z. ^{[2
]}

Nugumanova, Gulnara N. ^{[1
]}

机构：

[1] Kazan Natl Res Technol Univ, Kazan, Russia

[2] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Inst Organ & Phys Chem, 8 Akad Arbuzova St, Kazan 420088, Russia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2016年 / 191卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

Isatin; phosphonate; sterically hindered phenol; antioxidants; HYDRAZONES;

D O I：

10.1080/10426507.2016.1138308

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of N-[dimethoxyphosphoryl-(3,5-di-tert-butyl-4-hydroxyphenyl)] methylisatins has been performed by the addition of isatin and 5-butylisatin to the double bond of dimethyl-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadienylidene)methylphosphonate. Subsequent functionalization of the compounds synthesized with thiosemicarbazide hydrochloride, 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid hydrazide, and isonicotinic acid. Hydrazide gave isatin derivatives containing several pharmacophore fragments. Each of them has the ability to the increase the antioxidant and biological activities of these compounds. [GRAPHICS]

引用

页码：1069 / 1074

页数：6

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