Synthesis, microwave-promoted catalytic activity in Suzuki-Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group

被引：40

作者：

Yilmaz, Ulku ^{[1
]}

Kucukbay, Hasan ^{[1
]}

Sireci, Nihat ^{[2
]}

Akkurt, Mehmet ^{[3
]}

Gunal, Selami ^{[4
]}

Durmaz, Riza ^{[4
]}

Tahir, M. Nawaz ^{[5
]}

机构：

[1] Inonu Univ, Fac Sci & Arts, Dept Chem, TR-44280 Malatya, Turkey

[2] Adiyaman Univ, Fac Educ, TR-02040 Adiyaman, Turkey

[3] Erciyes Univ, Fac Sci, Dept Phys, TR-38039 Kayseri, Turkey

[4] Inonu Univ, Fac Med, Dept Microbiol, TR-44280 Malatya, Turkey

[5] Univ Sargodha, Dept Phys, Sargodha, Pakistan

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2011年 / 25卷 / 05期

关键词：

benzimidazole salt; carbene; palladium catalysis; coupling reaction; Suzuki-Miyaura coupling; microwave; antimicrobial activity; CARBENE COMPLEXES; SUBSTITUTED BENZIMIDAZOLE; ARYL CHLORIDES; PALLADIUM; HECK; ANTIBACTERIAL; PRECATALYSTS; DERIVATIVES; SYSTEM; WATER;

D O I：

10.1002/aoc.1772

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A mixture of benzimidazole salts (2-7), Pd(OAc)(2) and K2CO3 in DMF-H2O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by H-1-C-13, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：366 / 373

页数：8

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