RETRACTED: Targeting TGF-β1 and AKT signal on growth and metastasis of anaplastic thyroid cancer cell in vivo (Retracted article. See vol. 24, pg. 7208, 2020)

被引：0
|
作者：
Li, Y. [1 ]
Chen, D. [1 ]
Hao, F. -Y. [2 ]
Zhang, K. -J. [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Gen Surg, Qingdao, Peoples R China
[2] Qingdao Univ, Affiliated Hosp, Dept Pathol, Qingdao, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2016年 / 20卷 / 12期
关键词：
Anaplastic thyroid cancer; TGF-D; Phosphatidylinositol 3-kinase (PI3K)/AKT; INHIBITOR MK-2206; PHASE-II; TGF-BETA; EXPRESSION; ACTIVATION; CARCINOMA; SYNERGIZES; MK2206; KINASE; TRIAL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: We have recently reported that therapies targeting TGF-beta 1 signaling were effective to prevent the anaplastic thyroid cancer (ATC) cell growth, but not the invasion. Phosphatidylinositol 3-kinase (PI3K)/AKT signaling are activated in ATC and play a major role in ATC invasion. Herein, we examined the effects of targeting TGF-beta 1 by shRNA in combination with pan-AKT inhibitor, MK-2206 on growth and metastasis of ATC xenografts implanted in severe combined immunodeficient mice. MATERIALS AND METHODS: 8505C cells or 8505C/shRNA cells or 8505C/TGF-beta 1 shRNA cells were implanted sc in 5-week-old female nude mice. Upon establishment of palpable tumours, MK-2206 was administered at 60 mg/kg, orally, three times a week for 6 weeks. RESULTS: The results showed that TGF-beta 1/shRNA alone only prevents anaplastic thyroid cancer (ATC) tumor formation, but not lung metastasis. MK-2206 alone only inhibits lung metastasis, but not tumor formation. The combined treatment with TGF-beta 1/shRNA and MK-2206 led to an approximately 71% growth inhibition compared with TGF-beta 1/shRNA (44%) and MK-2206 (15%). The combined treatment with TGF-beta 1/shRNA and MK-2206 significantly inhibits lung metastasis. CONCLUSIONS: These findings demonstrated that targeting TGF-beta 1 in combination with MK-2206 was the effective method for treatment of ATC.
引用
收藏
页码：2581 / 2587
页数：7
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