Identification of the MHC class IB locus in cynomolgus monkeys

被引：26
|
作者：
Uda, A
Tanabayashi, K
Fujita, O
Hotta, A
Terao, K
Yamada, A
机构：
[1] Natl Inst Infect Dis, Dept Vet Sci, Shinjuku Ku, Tokyo 1628640, Japan
[2] Natl Inst Infect Dis, Tsukuba Primate Ctr Med Sci, Tsukuba, Ibaraki 3050843, Japan
来源：
IMMUNOGENETICS | 2005年 / 57卷 / 3-4期
关键词：
cynomolgus; MHC; Mafa; allele;
D O I：
10.1007/s00251-005-0782-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.
引用
收藏
页码：189 / 197
页数：9
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