Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

被引：571

作者：

Wang, Yinghong ^{[1
]}

Wiesnoski, Diana H. ^{[2
]}

Helmink, Beth A. ^{[3
]}

Gopalakrishnan, Vancheswaran ^{[3
]}

Choi, Kati ^{[4
]}

DuPont, Hebert L. ^{[5
,6
]}

Jiang, Zhi-Dong ^{[5
]}

Abu-Sbeih, Hamzah ^{[1
]}

Sanchez, Christopher A. ^{[2
]}

Chang, Chia-Chi ^{[2
]}

Parra, Edwin R. ^{[7
]}

Francisco-Cruz, Alejandro ^{[7
]}

Raju, Gottumukkala S. ^{[1
]}

Stroehlein, John R. ^{[1
]}

Campbell, Matthew T. ^{[8
]}

Gao, Jianjun ^{[8
]}

Subudhi, Sumit K. ^{[8
]}

Maru, Dipen M. ^{[9
]}

Blando, Jorge M. ^{[10
]}

Lazar, Alexander J. ^{[9
]}

Allison, James P. ^{[10
]}

Sharma, Padmanee ^{[10
]}

Tetzlaff, Michael T. ^{[7
,9
]}

Wargo, Jennifer A. ^{[2
,3
]}

Jenq, Robert R. ^{[2
,11
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Div Internal Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Div Canc Med, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Div Surg, Dept Surg Oncol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA

[5] Univ Texas Houston, Ctr Infect Dis, Sch Publ Hlth, Houston, TX USA

[6] Kelsey Res Fdn, Houston, TX USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Div Pathol Lab Med, Houston, TX 77030 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Div Canc Med, Houston, TX 77030 USA

[9] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Div Pathol Lab Med, Houston, TX 77030 USA

[10] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Div Basic Sci Res, Houston, TX 77030 USA

[11] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2018年 / 24卷 / 12期

基金：

美国国家卫生研究院;

关键词：

CYTOTOXIC T-CELLS; ADVERSE EVENTS; BLOCKADE; IMMUNOTHERAPY; IPILIMUMAB; CANCER;

D O I：

10.1038/s41591-018-0238-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

引用

页码：1804 / +

页数：7

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