Preventive Effects of Taurine on Development of Hepatic Steatosis Induced by a High-Fat/Cholesterol Dietary Habit

被引：95

作者：

Chang, Yuan-Yen ^{[2
,3
,5
]}

Chou, Chung-Hsi ^{[6
,7
]}

Chiu, Chih-Hsien ^{[1
]}

Yang, Kuo-Tai ^{[8
]}

Lin, Yi-Ling ^{[4
]}

Weng, Wei-Lien ^{[9
]}

Chen, Yi-Chen ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan

[2] Chung Shan Med Univ, Dept Microbiol & Immunol, Sch Med, Taichung 402, Taiwan

[3] Chung Shan Med Univ, Inst Microbiol & Immunol, Sch Med, Taichung 402, Taiwan

[4] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 402, Taiwan

[5] Chung Shan Med Univ Hosp, Clin Lab, Taichung 402, Taiwan

[6] Natl Taiwan Univ, Zoonoses Res Ctr, Taipei 106, Taiwan

[7] Natl Taiwan Univ, Sch Vet Med, Taipei 106, Taiwan

[8] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[9] Natl Yang Ming Univ, Inst Biochem, Taipei 112, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 01期

关键词：

Antioxidant capacity/enzyme; hepatic/fecal lipids; hepatic steatosis; lipid homeostasis; serum lipids; taurine; NONALCOHOLIC FATTY LIVER; CYSTEINE-CONTAINING COMPOUNDS; FLAXSEED OIL; CHOLESTEROL-METABOLISM; OXIDATIVE STRESS; ACID SYNTHESIS; DISEASE; ALPHA; MODEL; TRIACYLGLYCEROL;

D O I：

10.1021/jf103167u

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become an emergent liver disease in developed and developing nations. This study was to exam the preventive effects of taurine (Tau) on the development of hepatic steatosis via a hamster model. Although hepatic steatosis of hamsters was induced by feeding a high-fat/cholesterol diet, drinking water containing 0.35 and 0.7% Tau improved (p < 0.05) the serum lipid profile. Meanwhile, the smaller (p < 0.05) liver sizes and lower (p < 0.05) hepatic lipids in high-fat/cholesterol dietary hamsters drinking Tau may be partially due to higher (p < 0.05) fecal cholesterol, triacylglycerol, and bile acid outputs. In the regulation of lipid homeostasis, drinking a Tau solution upregulated (p < 0.05) low-density lipoprotein receptor and CYP7A1 gene expressions in high-fat/cholesterol dietary hamsters, which result in increased fecal cholesterol and bile acid outputs. Drinking a Tau solution also upregulated (p < 0.05) peroxisome proliferator-activated receptor-a (PPAR-a) and uncoupling protein 2 (UPC2) gene expressions in high-fat/cholesterol dietary hamsters, thus increasing energy expenditure. Besides, Tau also enhanced (p < 0.05) liver antioxidant capacities (GSH, TEAC, SOD, and CAT) and decreased (p < 0.05) lipid peroxidation (MDA), which alleviated liver damage in the high-fat/cholesterol dietary hamsters. Therefore, Tau shows preventive effects on the development of hepatic steatosis induced by a high-fat/cholesterol dietary habit.

引用

页码：450 / 457

页数：8

共 32 条

[1]

Bedogni Giorgio, 2004, Ann Hepatol, V3, P63

[2]

BELLENTANI S, 1987, J LIPID RES, V28, P1021

[3]

Carson FL, 1990, HISTOTECHNOLOGY SELF, P1

[4] Intracellular antioxidants:: from chemical to biochemical mechanisms [J].

Chaudière, J ;

Ferrari-Iliou, R .

FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (9-10) :949-962

[5]

Daggy BP, 1997, J LIPID RES, V38, P491

[6] Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats [J].

Fisher, Craig D. ;

Lickteig, Andrew J. ;

Augustine, Lisa M. ;

Elferink, Ronald P. J. Oude ;

Besselsen, David G. ;

Erickson, Robert P. ;

Cherrington, Nathan J. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 613 (1-3) :119-127

[7] Oxidative stress in vascular disease:: causes, defense mechanisms and potential therapies [J].

Foerstermann, Ulrich .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2008, 5 (06) :338-349

[8] Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice [J].

Hong, Jung Hee ;

Lee, In Seon .

CHEMICO-BIOLOGICAL INTERACTIONS, 2009, 179 (2-3) :88-93

[9] SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver [J].

Horton, JD ;

Goldstein, JL ;

Brown, MS .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1125-1131

[10] Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet [J].

Hsu, Tsai-Ching ;

Chiang, Szu-Yi ;

Wu, Jen-Huang ;

Tsai, Chun-Chou ;

Huang, Chih-Yang ;

Chen, Yi-Chen ;

Tzang, Bor-Show .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (20) :9685-9691

← 1 2 3 4 →