Neural and behavioral epigenetics; what it is, and what is hype

被引:26
作者
Isles, A. R. [1 ]
机构
[1] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Behav Genet Grp, Neurosci & Mental Hlth Res Inst, Cardiff CF24 4HQ, Wales
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
Animal models; behavioral plasticity; chromatin; DNA-methylation; environment; epigenetics; genomic imprinting; histones; neurodevelopment; transcription; DNA METHYLATION; DELTA-FOSB; HISTONE ACETYLATION; MEMORY FORMATION; DYNAMIC CHANGES; PREOPTIC AREA; BRAIN; EXPRESSION; MECHANISMS; MECP2;
D O I
10.1111/gbb.12184
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The ability to examine epigenetic mechanisms in the brain has become readily available over the last 20 years. This has led to an explosion of research and interest in neural and behavioral epigenetics. Of particular interest to researchers, and indeed the lay public, is the possibility that epigenetic processes, such as changes in DNA-methylation and histone modification, may provide a biochemical record of environmental effects. This has led to some fascinating insights into how molecular changes in the brain can control behavior. However, some of this research has also attracted controversy and, as is dealt with here, some overblown claims. This latter problem is partly linked to the shifting sands of what is defined as epigenetics'. In this review, I provide an overview of what exactly epigenetics is, and what is hype, with the aim of opening up a debate as to how this exciting field moves forward.
引用
收藏
页码:64 / 72
页数:9
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