Comorbidity of long COVID and psychiatric disorders after a hospitalisation for COVID-19: a cross-sectional study

被引：39

作者：

Gasnier, Matthieu ^{[1
,2
]}

Choucha, Walid ^{[1
,2
]}

Radiguer, Francois ^{[3
]}

Faulet, Theo ^{[1
,2
]}

Chappell, Kenneth ^{[1
,2
]}

Bougarel, Aurore ^{[1
]}

Kondarjian, Christian ^{[1
]}

Thorey, Paul ^{[1
]}

Baldacci, Antoine ^{[1
]}

Ballerini, Maryne ^{[1
]}

Ait Tayeb, Abd El Kader ^{[1
,2
]}

Herrero, Hugo ^{[1
,2
]}

Hardy-Leger, Isabelle ^{[4
]}

Meyrignac, Olivier ^{[5
]}

Morin, Luc ^{[6
]}

Lecoq, Anne-Lise ^{[7
]}

Pham, Tai ^{[8
]}

Noel, Nicolas

Jollant, Fabrice ^{[1
,2
]}

Montani, David ^{[9
]}

Monnet, Xavier ^{[9
]}

Becquemont, Laurent ^{[2
]}

Corruble, Emmanuelle ^{[1
,2
]}

Colle, Romain ^{[1
,2
]}

机构：

[1] Hop Univ Paris Saclay, Assistance Publ Hop Paris, Mood Ctr Paris Saclay, Serv Hosp Univ Psychiatrie Bicet,Hop Bicetre, Le Kremlin Bicetre, France

[2] Univ Paris Saclay, MOODS Team, INSERM 1018, Ctr Rech Epidemiol & Sante Populat,Fac Med, Le Kremlin Bicetre, France

[3] Hop Bicetre, Assistance Publ Hop Paris, Serv reanimat chirurgicale, Paris, France

[4] Hop Bicetre, Assistance Publ Hop Paris, Serv med interne & immunol clin, Paris, France

[5] Hop Bicetre, Assistance Publ Hop Paris, Serv radiol diagnost & interventionnelle, Paris, France

[6] Hop Bicetre, Assistance Publ Hop Paris, Serv reanimat pediatr & med neonatale, Paris, France

[7] Hop Univ Paris Saclay, Hop Bicetre, Assistance Publ Hop Paris, Ctr Rech Clin, Paris, France

[8] Hop Bicetre, Assistance Publ Hop Paris, Serv med intens reanimat, Paris, France

[9] Hop Bicetre, Assistance Publ Hop Paris, Serv pneumol & soins intensifs respiratoires, Paris, France

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2022年 / 93卷 / 10期

关键词：

COVID-19; psychiatry; depression; behavioural disorder; VALIDATION; DEPRESSION; SURVIVORS; SCALE;

D O I：

10.1136/jnnp-2021-328516

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives Long COVID is a major public health issue. Whether long COVID is comorbid with psychiatric disorders remains unclear. Here, we investigate the association between long COVID, psychiatric symptoms and psychiatric disorders. Design Cross-sectional. Settings Bicetre Hospital, France, secondary care. Participants One hundred seventy-seven patients admitted in intensive care unit during acute phase and/or reporting long COVID complaints were assessed 4 months after hospitalisation for an acute COVID. Main outcome measures Eight long COVID complaints were investigated: fatigue, respiratory and cognitive complaints, muscle weakness, pain, headache, paraesthesia and anosmia. The number of complaints, the presence/absence of each COVID-19 complaint as well as lung CT scan abnormalities and objective cognitive impairment) were considered. Self-reported psychiatric symptoms were assessed with questionnaires. Experienced psychiatrists assessed Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-based diagnoses of psychiatric disorders. Results One hundred and fifteen (65%) patients had at least one long COVID complaint. The number of long COVID complaints was associated with psychiatric symptoms. The number of long COVID complaints was higher in patients with psychiatric disorders (mean (m) (SD)=2.47 (1.30), p<0.05), new-onset psychiatric disorders (m (SD)=2.41 (1.32), p<0.05) and significant suicide risk (m (SD)=2.67 (1.32), p<0.05) than in patients without any psychiatric disorder (m (SD)=1.43 (1.48)). Respiratory complaints were associated with a higher risk of psychiatric disorder and new-onset psychiatric disorder, and cognitive complaints were associated with a higher risk of psychiatric disorder. Conclusions Long COVID is associated with psychiatric disorders, new-onset psychiatric disorders and suicide risk. Psychiatric disorders and suicide risk should be systematically assessed in patients with long COVID.

引用

页码：1091 / 1098

页数：8

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