Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation

被引：35
作者：
Duvall, Melody G. [1 ,2 ]
Bruggemann, Thayse R. [1 ,3 ]
Levy, Bruce D. [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Perioperat & Pain Med, Div Crit Care Med, Boston, MA 02115 USA
[3] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, Sao Paulo, Brazil
来源：
MOLECULAR ASPECTS OF MEDICINE | 2017年 / 58卷
基金：
美国国家卫生研究院; 巴西圣保罗研究基金会;
关键词：
Lipoxins; Resolvins; Protectins; Maresins; Catabasis; Efferocytosis; Lung; Leukocytes; Airway; Mucosa; A(4) STABLE ANALOGS; DAMPENS AIRWAY INFLAMMATION; EXHALED BREATH CONDENSATE; PROTEIN-COUPLED RECEPTOR; LIPOXIN A(4); CYSTIC-FIBROSIS; LIPID MEDIATORS; EPITHELIAL-CELLS; PROMOTES RESOLUTION; INFLUENZA-VIRUS;
D O I：
10.1016/j.mam.2017.04.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bronchi are exposed daily to irritants, microbes and allergens as well as extremes of temperature and acid. The airway mucosal epithelium plays a pivotal role as a sentinel, releasing alarmins when danger is encountered. To maintain homeostasis, an elaborate counter-regulatory network of signals and cellular effector mechanisms are needed. Specialized pro-resolving mediators (SPMs) are chemical mediators that enact resolution programs in response to injury, infection or allergy. SPMs are enzymatically derived from essential polyunsaturated fatty acids with potent cell-type specific immunoresolvent properties. SPMs signal by engaging cell-based receptors to turn off acute inflammatory responses and restore tissue homeostasis. Several common lung diseases involving the airways, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF), are characterized by unresolved bronchial inflammation. In preclinical murine models of lung disease, SPMs carry potent bronchoprotective actions. Here, we review cellular and molecular effects for SPM-initiated catabasis in the lung and their human translation. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：44 / 56
页数：13
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