Formation of an inclusion complex of a new transition metal ligand in β-cyclodextrin

被引：5

作者：

Khemtong, C ^{[1
]}

Banerjee, D ^{[1
]}

Liu, YB ^{[1
]}

El Khoury, JM ^{[1
]}

Rinaldi, PL ^{[1
]}

Hu, J ^{[1
]}

机构：

[1] Univ Akron, Dept Chem, Akron, OH 44325 USA

来源：

SUPRAMOLECULAR CHEMISTRY | 2005年 / 17卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

tripodal transition metal ligand; 2,4,9-trithiaadamantane; beta-cyclodextrin; inclusion complex; NOESY; association constant;

D O I：

10.1080/10610270500115563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inclusion complex of a new transition metal ligand, 2,4,9-trithia-tricyclo[3.3.1.1(3,7)] decane-7-carboxylic acid (2,4,9-trithia-adamantane-7-carboxylic acid, TPCOOH) in beta-cyclodextrin was studied by H-1 NMR, 2D NOESY NMR spectroscopy, host-induced CD spectroscopy, and tandem mass spectrometry. H-1 NMR, MS-MS and NOESY data show that the TPCOOH guest forms a 1:1 inclusion complex with the host beta-cyclodextrin. The NOESY experiments also show that TPCOOH is oriented in the complex with the thioketal end preferentially located at the larger opening of beta-cyclodextrin. The orientation of the guest in the host molecule is also confirmed by the induced CD of the ligand, which shows a positive Cotton effect. An association constant of 660 +/- 20 M-1 was determined by H-1 NMR titration for the complex at room temperature in D2O.

引用

页码：335 / 341

页数：7

共 16 条

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