共 167 条
Discriminating self from non-self in nucleic acid sensing
被引:433
作者:

Schlee, Martin
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机构:
Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany

Hartmann, Gunther
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Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany
机构:
[1] Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany
关键词:
DOUBLE-STRANDED-RNA;
GMP-AMP SYNTHASE;
INNATE IMMUNE SENSOR;
RECEPTOR RIG-I;
TOLL-LIKE RECEPTOR-3;
PLASMACYTOID DENDRITIC CELLS;
SMALL INTERFERING RNA;
VIRAL MESSENGER-RNA;
IFIT FAMILY-MEMBERS;
INDUCIBLE GENE-I;
D O I:
10.1038/nri.2016.78
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses.
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收藏
页码:566 / 580
页数:15
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