Discriminating self from non-self in nucleic acid sensing

被引:433
作者
Schlee, Martin [1 ]
Hartmann, Gunther [1 ]
机构
[1] Univ Bonn, Univ Hosp, Inst Clin Chem & Clin Pharmacol, Sigmund Freud Str 25, D-53127 Bonn, Germany
关键词
DOUBLE-STRANDED-RNA; GMP-AMP SYNTHASE; INNATE IMMUNE SENSOR; RECEPTOR RIG-I; TOLL-LIKE RECEPTOR-3; PLASMACYTOID DENDRITIC CELLS; SMALL INTERFERING RNA; VIRAL MESSENGER-RNA; IFIT FAMILY-MEMBERS; INDUCIBLE GENE-I;
D O I
10.1038/nri.2016.78
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses.
引用
收藏
页码:566 / 580
页数:15
相关论文
共 167 条
[71]   Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA [J].
Judge, AD ;
Sood, V ;
Shaw, JR ;
Fang, D ;
McClintock, K ;
MacLachlan, I .
NATURE BIOTECHNOLOGY, 2005, 23 (04) :457-462
[72]   Translating nucleic acid-sensing pathways into therapies [J].
Junt, Tobias ;
Barchet, Winfried .
NATURE REVIEWS IMMUNOLOGY, 2015, 15 (09) :529-544
[73]   Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA [J].
Karikó, K ;
Buckstein, M ;
Ni, HP ;
Weissman, D .
IMMUNITY, 2005, 23 (02) :165-175
[74]   Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses [J].
Kato, H ;
Takeuchi, O ;
Sato, S ;
Yoneyama, M ;
Yamamoto, M ;
Matsui, K ;
Uematsu, S ;
Jung, A ;
Kawai, T ;
Ishii, KJ ;
Yamaguchi, O ;
Otsu, K ;
Tsujimura, T ;
Koh, CS ;
Sousa, CRE ;
Matsuura, Y ;
Fujita, T ;
Akira, S .
NATURE, 2006, 441 (7089) :101-105
[75]   Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 [J].
Kato, Hiroki ;
Takeuchi, Osamu ;
Mikamo-Satoh, Eriko ;
Hirai, Reiko ;
Kawai, Tomoji ;
Matsushita, Kazufumi ;
Hiiragi, Akane ;
Dermody, Terence S. ;
Fujita, Takashi ;
Akira, Shizuo .
JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1601-1610
[76]   Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS [J].
Kato, Kazuki ;
Ishii, Ryohei ;
Goto, Eiji ;
Ishitani, Ryuichiro ;
Tokunaga, Fuminori ;
Nureki, Osamu .
PLOS ONE, 2013, 8 (10)
[77]   Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages [J].
Kawane, Kohki ;
Ohtani, Mayumi ;
Miwa, Keiko ;
Kizawa, Takuji ;
Kanbara, Yoshiyuki ;
Yoshioka, Yoshichika ;
Yoshikawa, Hideki ;
Nagata, Shigekazu .
NATURE, 2006, 443 (7114) :998-1002
[78]   Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity [J].
Kawasaki, Takumi ;
Kawai, Taro ;
Akira, Shizuo .
IMMUNOLOGICAL REVIEWS, 2011, 243 :61-73
[79]   An enteric virus can replace the beneficial function of commensal bacteria [J].
Kernbauer, Elisabeth ;
Ding, Yi ;
Cadwell, Ken .
NATURE, 2014, 516 (7529) :94-U223
[80]   IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection [J].
Kerur, Nagaraj ;
Veettil, Mohanan Valiya ;
Sharma-Walia, Neelam ;
Bottero, Virginie ;
Sadagopan, Sathish ;
Otageri, Pushpalatha ;
Chandran, Bala .
CELL HOST & MICROBE, 2011, 9 (05) :363-375