Construction of PDA/RGDC/Zinc Oxide Quantum Dot Composite Coatings with Antibacterial Activity and Biocompatibility on Surface of Titanium Implants

被引：1
作者：
Yu Yi [1 ]
Xiang Yiming [1 ]
Li Yilang [1 ]
Tan Lei [1 ]
Liu Xiangmei [1 ]
Wu Shuilin [2 ]
机构：
[1] Hubei Univ, Sch Mat Sci & Engn, Wuhan 430062, Peoples R China
[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China
来源：
CHINA SURFACE ENGINEERING | 2019年 / 32卷 / 05期
基金：
国家重点研发计划;
关键词：
implants; antibacterial; biocompatibility; zinc oxide quantum (ZnO QDs); arginine-glycine-aspartic acid-cysteine (RGDC) peptides; ZINC; DISSOLUTION; POLYMERS; RELEASE;
D O I：
10.11933/j.issn.1007-9289.20190319004
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Traditional antibiotics to treat bacterial infections often lead to bacterial resistance to antibiotics, leading to the formation of drug-resistant bacteria, which has a greater risk to human health. A novel surface system was designed to provide a reliable self-antimicrobial platform for titanium implants without the use of antibiotics. This feature was achieved by constructing the composite coating on PDA(polydopamine)/RGDC (arginine-glycine-aspartic acid-cysteine)/zinc oxide quantum dot (ZnO QDs) on titanium implant surface. The ZnO QDs obtained by particle growth method was modified by RGDC and connected to the PDA covering the surface on titanium implant. The composite coating was tested with different bacteria and mouse osteoblasts. The results show that it has an antibacterial rate against Escherichia coli up to 98.95% and has excellent biocompatibility. Hence, the surface coating will have a broad application prospect in the field of biomedical implant materials.
引用
收藏
页码：13 / 21
页数：9
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