Optimum Chemotherapy Regimens for Neoadjuvant Therapy of Hepatic Colorectal Metastases

被引：3

作者：

Davies, Janine M. ^{[1
]}

Goldberg, Richard M. ^{[1
]}

机构：

[1] Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 102卷 / 08期

关键词：

colorectal neoplasms; metastases; liver; neoadjuvant chemotherapy; targeted therapy; combination chemotherapy; OXALIPLATIN-BASED CHEMOTHERAPY; UNRESECTABLE LIVER METASTASES; PHASE-II TRIAL; 1ST-LINE TREATMENT; PREOPERATIVE CHEMOTHERAPY; FOLINIC ACID; RANDOMIZED-TRIAL; COLON-CANCER; RESECTION; FLUOROURACIL;

D O I：

10.1002/jso.21653

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resection of metastatic colorectal cancer hepatic lesions has gained support as surgical advances have made resections safer. Subsequently, the use of neoadjuvant therapy to cytoreduce tumors coupled with improved medical therapy has enhanced resection rates leading to improved outcomes. In "unresectable'' disease, the addition of biologic therapies has further enhanced antitumor response, resulting in successful disease resection in certain patients. This review examines approaches to the neoadjuvant management of colorectal liver metastases with systemic therapies. J. Surg. Oncol. 2010; 102: 946-954. (C) 2010 Wiley-Liss, Inc.

引用

页码：946 / 954

页数：9

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